TCA cycle

Question 1

TCA cycle aerobic or anaerobic ?

Answer 1

Aerobic

Question 2

Where does TCA cycle occurs in cell

Answer 2

Mitochondria

Question 3

Where is pyruvate converted to acetyl CoA

Answer 3

Matrix of mitochondria

Question 4

Citrate synthesis from OAA and acetyl coa catalyzed by

Answer 4

Citrate synthase

Question 5

Rate limiting step of tca cycle

Answer 5

isocitrate to a-KG by isocitrate dehydrogenase

Activated by high ADP and Ca2+
Inhibited by ATP and NADH

Question 6

a ketoglutarate dehydrogenase complex concert

Answer 6

a ketoglutarate to succinyl coa

Question 7

Step of TCA where FADH2 is produced

Answer 7

Succincte to fumarate because succincte can’t reduce NAD+

Question 8

Steps where NADH is produced

Answer 8

Isocitrate to a ketoglutarate
a ketoglutarate to succinyl coa
Malate to oxaloacetate

Question 9

Step where GTP is produced

Answer 9

Succinyl coa to succinate

Question 10

Total energy formed by TCA

Answer 10

3 NADH -> 9 ATP
1 FADH2 -> 2 ATP
1 GTP -> 1 ATP

So 12 ATP per acetyl coa