Pentoss Phosphate Pathway

Question 1

pathway responsible for NADPH production

Answer 1

PPP

Question 2

PPP rate limiting step

Answer 2

Glucose 6 phosphate dehydrogenase

Converts glucose 6 pi to 6phosphogluconolactone

Question 3

2 steps of PPP where NADPH produced

Answer 3

Glucose6pi —> 6 phosphogluconolactone
>by glucose 6 pi dehydrogenase

6phosphogluconate —> ribulose 5 pi
>by 6phosphogluconate dehydrogenase

Question 4

Last product of oxidative stage of PPP

Answer 4

Ribulose 5 pi

Question 5

Non oxidative pathway of PPP

Answer 5

Ribulose 5 pi converted to glyceraldehyde3pi and fructose6pi

TransKetolase and transaldolase rxn

Question 6

When you need ribose 5 pi but not NADP what happens

Answer 6

Glycolysis and reversal of non oxidative rxn

Question 7

What happens if body need both NDPH and ribose 5 pictures b

Answer 7

Oxidative rxn of PPP used

Question 8

What happens if body needs only NADPH but not ribose 5 pi

Answer 8

Both oxidative and non oxidative rxn a are used

C3 and C6 used to generate ATP or glucose

Question 9

Wernicke korsakoff syndrome

Answer 9

Neuropsychiatric disorder
- Difficulty in eye movements abnormal gait mental dysfunction

Due to transketolase defective binding to thiamine pyrophosphate

Question 10

Hemolytic anemia

Answer 10

Deficiency in glucose 6 phosphate dehydrogenase in red blood cells

Prevents formation of NADPH during pentose phosphate pathway
NADPH normally required for detoxifying oxidizing agents