Glycogen Flashcards
Structure of glycogen
a 1,4 glucosidic bond
a 1,6 glycosidic bond every 8-10 residues
Phosphoglucomutase converts …
Glucose to glucose 1 pi
Udp glucose pyrophosphorylase converts
Glucose 1 pi to UDP glucose
What enzyme makes the a1,4 glycosidic bond
Glycogen synthase
Protein on glycogen that help accept new glucose from glucose udp and act as enzyme to form primer
Glycogenin
Amylo a 1-4 to 1-6 transglucosidase (branching enzyme)
Form branch of a1,6
Enzyme that helps degrade a1,4 bond in glycogen
Glycogen phosphorylase
Enzyme responsible for removal of branc
Debranching enzyme
Glucose 1-pi to glucose 6pi converted by
Phosphoglucomutase
Glycogenolysis only produce glucose in liver because ..
Glucose 6 phosphatase only found in liver
Glycogenolysis activated by
Glucagon
Epinephrine
cAMP directed dégradation of glycogen pathway
Glucagon / epinephrine binds to GPCR
cAMP synthesized
Pka activated
Pka phosphorylates inactive phosphorylase kinase b which becomes active phosphorylase kinase a
Phosphorylase kinase a phosphorylates inactive glycogen phosphorylase b which becomes active glycogen phosphorylase a
Glycogen phosphorylase a undergo glycogenolysis
cAMP directed inhibition of glycogen synthesis
Glycogen synthase activated when dephosporylqted and inactive when phosphorylated
Pka activated by cAMP can phosphorylate glycogen synthase which will inhibit it
In well fed state, glycogen synthase b is allosterically …. by …
Activated by glucose 6 pi
In well fed state, glycogen phosphorylase a is allosterically …. by …
Inhibited by glucose 6 pi and ATP
In liver by also glucose itself
