T1 L4 & 5 Calcium homeostasis Flashcards
What can cause too much hormone to be produced?
Single nodule
Multiple nodules
Generalised increase in tissue (hyperplasia)
What are the layers of the adrenal glands?
Zona glomerulosa
Zona fasciculata
Zona reticularis
Medulla
What is primary hyperaldosteronism?
Conn’s syndrome
Excess production of hormone aldosterone from the adrenal glands which leads to low renin levels
Occurs in zona glomerulosa
What are the adrenal causes of hypertension?
Primary hyperaldosteronism
Phaeochromocytoma
What are the causes of too much aldosterone in the zona glomerulosa?
Adenoma
Hyperplasia
Rare genetic causes
What hypertensive patients should be screened?
Hypokalaemia
Resistant hypertension
Younger people
What tests can be used to diagnose primary hyperaldosteronism?
Initial screening tests: suppressed renin, normal / high aldosterone
Confirmatory tests: oral or Iv sodium suppression test
What tests can be done to find the cause of primary hyperaldosteronism?
Adrenal CT scan
Adrenal venous sampling
Metomidate PET CT
What treatment is given for unilateral adenoma?
Laparoscopic adrenalectomy
Medical treatment
What treatment is given for bilateral hyperplasia?
Medical treatment (aldosterone antagonists) Spironolactone Eplerinone
What does phaeochromocytoma cause?
Increased adrenaline and noradrenaline leading to raised BP
What catecholamines does the adrenal medulla produce?
Dopamine
Norepinephrine
Epinephrine
How does phaeochromocytoma present?
Spells of headache, sweating, pallor, palpitation, anxiety
Hypertension (permanent or intermittent)
What genetic conditions are associated with phaeochromocytoma?
Neurofibromatosis type 1 (NF1)
Multiple endocrine neoplasia type 2 (MEN 2)
Von Hippel-Lindau syndrome
What is the biochemical diagnosis for phaeochromocytoma?
24 hour urine: normetanephrines and metanephrines will be high. 3 methoxytyromine
Plasma: noradrenalin, adrenalin and metanephrines