T1 L17 Acute complications of diabetes Flashcards
What is diabetic ketoacidosis?
Insulin deficiency leading to ketosis and acidosis
What are the general effects of insulin deficiency?
Glycogenolysis in the liver by glucagon, adrenaline and cortisol
Lipolysis and reduced esterification of fatty acids in adipose tissue
Proteolysis and reduced uptake of amino acids in the muscle
Increased hepatic glucose output and hyperglycaemia
What is the pathophysiology of DKA?
Unchecked gluconeogenesis –> hyperglycaemia
Osmotic diuresis –> dehydration
Unchecked ketogenesis –> ketosis
Dissociation of ketone bodies into hydrogen ion and anions leading to anion-gap metabolic acidosis
When does ketoacidosis occur?
When ketone body production exceeds the rate of utilising in peripheral tissues and renal clearance
Describe what happens in adipose tissue during DKA
Increased lipolysis and reduced esterification of fat causes excess FFA and glycerol
FFA are a substrate for hepatic synthesis of ketone bodies
How is the acidosis in DKA managed by the body?
Intracellular buffering - H/K exchange
Respiratory compensation - hyperventilation
- the H+ stimulate the respiratory centres to breath out more CO2
Describe the electrolyte disturbances in DKA
Potassium depletion
Sodium depletion leading to dehydration
What is the common group for DKA?
Mostly young T1DM
What are the precipitating causes of DKA?
Infections - pneumonia, UTI, viral illness, gastroenteritis Error / missed insulin administration Myocardial infarction Previously undiagnosed type 1 diabetes Drugs - steroids
What is the serum sodium in DKA?
Normal or low
What is the blood glucose in DKA?
< 40mmol/l
What is the serum bicarbonate and pH in DKA?
<14mmol/l
<7.3
What is the serum ketones in DKA?
Positive
What are the symptoms and signs caused by hyperglycaemia and dehydration in DKA?
Thirst and polyuria Weakness and malaise Dehydration and confusion Dry mouth and sunken eyes Postural or supine hypotension Hypothermia or coma
What are the symptoms and signs caused by acidosis in DKA?
Nausea and vomiting Abdominal pain Breathlessness Facial flush Hyperventilation Smell of ketones on breath and ketonuria