T1 L17 Acute complications of diabetes Flashcards

1
Q

What is diabetic ketoacidosis?

A

Insulin deficiency leading to ketosis and acidosis

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2
Q

What are the general effects of insulin deficiency?

A

Glycogenolysis in the liver by glucagon, adrenaline and cortisol
Lipolysis and reduced esterification of fatty acids in adipose tissue
Proteolysis and reduced uptake of amino acids in the muscle
Increased hepatic glucose output and hyperglycaemia

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3
Q

What is the pathophysiology of DKA?

A

Unchecked gluconeogenesis –> hyperglycaemia
Osmotic diuresis –> dehydration
Unchecked ketogenesis –> ketosis
Dissociation of ketone bodies into hydrogen ion and anions leading to anion-gap metabolic acidosis

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4
Q

When does ketoacidosis occur?

A

When ketone body production exceeds the rate of utilising in peripheral tissues and renal clearance

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5
Q

Describe what happens in adipose tissue during DKA

A

Increased lipolysis and reduced esterification of fat causes excess FFA and glycerol
FFA are a substrate for hepatic synthesis of ketone bodies

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6
Q

How is the acidosis in DKA managed by the body?

A

Intracellular buffering - H/K exchange
Respiratory compensation - hyperventilation
- the H+ stimulate the respiratory centres to breath out more CO2

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7
Q

Describe the electrolyte disturbances in DKA

A

Potassium depletion

Sodium depletion leading to dehydration

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8
Q

What is the common group for DKA?

A

Mostly young T1DM

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9
Q

What are the precipitating causes of DKA?

A
Infections - pneumonia, UTI, viral illness, gastroenteritis
Error / missed insulin administration
Myocardial infarction
Previously undiagnosed type 1 diabetes
Drugs - steroids
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10
Q

What is the serum sodium in DKA?

A

Normal or low

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11
Q

What is the blood glucose in DKA?

A

< 40mmol/l

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12
Q

What is the serum bicarbonate and pH in DKA?

A

<14mmol/l

<7.3

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13
Q

What is the serum ketones in DKA?

A

Positive

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14
Q

What are the symptoms and signs caused by hyperglycaemia and dehydration in DKA?

A
Thirst and polyuria
Weakness and malaise
Dehydration and confusion
Dry mouth and sunken eyes
Postural or supine hypotension
Hypothermia or coma
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15
Q

What are the symptoms and signs caused by acidosis in DKA?

A
Nausea and vomiting
Abdominal pain
Breathlessness
Facial flush
Hyperventilation
Smell of ketones on breath and ketonuria
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16
Q

What is the management plan in DKA?

A

1) Confirm diagnosis and check for precipitating causes
2) Rehydrate and monitor fluid balance - IV fluids (saline with added K), urinary catheter
3) Lower glucose - IV insulin
4) Monitor electrolytes - K and Na
5) Prevent clots - give low molecular weight heparin

17
Q

What is hyperosmolar hyperglycaemia state?

A

Relative insulin deficiency –> hyperglycaemia –> dehydration

18
Q

Why is there no breakdown of fats in HHS?

A

There is enough insulin still present

19
Q

What is the common group for HHS?

A

Usually above 40 years

20
Q

What are the precipitating causes of HHS?

A

Previously undiagnosed, steroids, diuretics, sugar

21
Q

What is the serum sodium in HHS?

A

Usually high

22
Q

What is the blood glucose in HHS?

A

Often >40mmol/l

23
Q

What is the serum bicarbonate and pH in HHS?

A

Normal

7.4

24
Q

What is the serum ketones in HHS?

A

0

25
Q

What is the management in HHS?

A

Confirm diagnosis and check for precipitating causes
Rehydrate and monitor fluid balance
Lower glucose once glucose isn’t improving with fluids by giving IV insulin
Monitor electrolytes
Prevent clots

26
Q

What is hypoglycaemia?

A

Blood sugar < 4mmol/l

27
Q

Why does the clinical syndrome associated with hypoglycaemia develop?

A

The nervous system becomes glucose deficient or neuroglycopaenic

28
Q

What are the causes of hypoglycaemia?

A

Insulin
- inappropriately excessive doses
- not eating or insufficient carbohydrates
Sulfonylureas

29
Q

What are the autonomic symptoms of hypoglycaemia?

A

Sweating, feeling hot
Trembling or shakiness
Anxiety
Palpitations

30
Q

What are the neuroglycopenic symptoms of hypoglycaemia?

A
Dizziness, light headedness
Tiredness
Hunger, nausea
Headache
Inability to concentrate, confusion, difficulty speaking, poor concentration, behavioural changes, automatism
Coma and convulsions, hemiplegia
31
Q

What is the counter-regulation in hypoglycaemia?

A

Glucagon, adrenaline, cortisol and GH have anti-insulin effects
Glucagon stimulates glycogenolysis and gluconeogenesis

Sympathetic nerves may directly activate hepatic glycogenolysis and stimulate glucagon secretion

32
Q

What is the treatment for a minor episode of hypoglycaemia?

A

20g carbohydrate as sugary drink, fruit juice, glucose tablets
Glucose gels

33
Q

What is the treatment for a hypoglycaemic coma?

A

IM or IV glucagon 1mg

IV dextrose 25g (150ml, 10% glucose)

34
Q

What would you give to treat DKA?

A

Insulin, fluids and potassium