T helper cells Flashcards
T helper cells are also known as
CD4 T cells
why are T helper cells also known as CD4 T cells
due to mature Th cells expressing the surface protein CD4
proliferating hyper T cells that develop into effector t cells (after activation by dendritic cell) differentiate into
Th1 and Th2 cell
T helper 1 cells
generate responses against intracellular parasites such as bacteria and viruses,
what triggers Th1 cells
Il-12
what are Th1s effector cytokines
IFN-y
TNF-alpha
IL-2
IL-3
main effector cells of Th1 immunity are
macrophages and CD8 T cells
T helper 2 cells
lead to humeral immune response- typically against extracellular pathogens (helminths)
what triggers Th2 cells
IL-4 and IL-2
effector cytokine of Th2
IL-4, IL-5, IL-9, IL-10, IL-13 and IL-25
main effectors cells of Th2
B cells, eosinophils, basophils, mast cells
