B cells

Question 1

B cells produce

Answer 1

antibodies

Question 2

antibodies convery

Answer 2

systemic protection- spread rapidly throughout the body through the blood

Question 3

antibody protection can be

Answer 3

convert to infant e.g. IgA

Question 4

B cell receptr

Answer 4

igG

Question 5

name 5 mechanism

Answer 5

neutralising
opsonising
complement
inflammation
ADCC

Question 6

role of B cell receptor

Answer 6

recognise antigen and trigger internal cascades to produce IgG

Question 7

antibody role

Answer 7

engage mechanisms of descrutction

Question 8

mechanisms of destruction

Answer 8

• binding with complement

- FC receptor (phagocytosis)

Question 9

IgM

Answer 9

primary response

Question 10

IgG

Answer 10

secondary response- immune memory, high affinity

Question 11

IgE

Answer 11

parasitic response

Question 12

IgD

Answer 12

??

Question 13

IgA

Answer 13

mucosal surfaces

Question 14

how many types of B cells

Answer 14

3

Question 15

name the three types of B cell

Answer 15

1) B1 cells
2) marginal zone antibodies
3) follicular antibodies

Question 16

B1 cells and marginal zone B cells

Answer 16

part of innate immunity- produce low affinity natural antibodies- do not require prior activation

Question 17

which B cells involved in adaptive immunity

Answer 17

Follicular B cells

Question 18

follicular B cells

Answer 18

require prior activation by T cells

Question 19

activation by T cells causes

Answer 19

clonal expansion and proliferation

Question 20

follicular B cells produce

Answer 20

highly diverse antibodies and prevent reinfeection

Question 21

T helper cells

Answer 21

direct B cells to switch to the production of other antibody isotopes

Question 22

switching isotopes does what

Answer 22

during immune response the average affinity of antibodies produced increases
- affinity maturation due to samtic mutation

Question 23

low level of high affinity antibodies…

Answer 23

are sufficient too prevention infection by virus- blocks entry

Question 24

block entry

Answer 24

neutralising

Question 25

extracellular bacteria and antibodies

Answer 25

become coated with antibodies- stimulated phagocytosis via FC - ADCC

Question 26

intracellular bacteria and antibodies

Answer 26

doesn’t work e.g. listeria, salmonella, m.Tb and meliondosis - cant reach pathogen

Question 27

antibodies prevent

Answer 27

re-infection e.g. by enteric bacteria- blocked from re-entering the gut

Question 28

only IgG

Answer 28

does phagocytosis and ADCC

Question 29

IgM an IgG ad IgA

Answer 29

neutralising and complement activation

Question 30

IgE

Answer 30

activation of mast cells ad basophils