B cells Flashcards
B cells produce
antibodies
antibodies convery
systemic protection- spread rapidly throughout the body through the blood
antibody protection can be
convert to infant e.g. IgA
B cell receptr
igG
name 5 mechanism
neutralising opsonising complement inflammation ADCC
role of B cell receptor
recognise antigen and trigger internal cascades to produce IgG
antibody role
engage mechanisms of descrutction
mechanisms of destruction
- binding with complement
- FC receptor (phagocytosis)
IgM
primary response
IgG
secondary response- immune memory, high affinity
IgE
parasitic response
IgD
??
IgA
mucosal surfaces
how many types of B cells
3
name the three types of B cell
1) B1 cells
2) marginal zone antibodies
3) follicular antibodies
B1 cells and marginal zone B cells
part of innate immunity- produce low affinity natural antibodies- do not require prior activation
which B cells involved in adaptive immunity
Follicular B cells
follicular B cells
require prior activation by T cells
activation by T cells causes
clonal expansion and proliferation
follicular B cells produce
highly diverse antibodies and prevent reinfeection
T helper cells
direct B cells to switch to the production of other antibody isotopes
switching isotopes does what
during immune response the average affinity of antibodies produced increases
- affinity maturation due to samtic mutation
low level of high affinity antibodies…
are sufficient too prevention infection by virus- blocks entry
block entry
neutralising
extracellular bacteria and antibodies
become coated with antibodies- stimulated phagocytosis via FC - ADCC
intracellular bacteria and antibodies
doesn’t work e.g. listeria, salmonella, m.Tb and meliondosis - cant reach pathogen
antibodies prevent
re-infection e.g. by enteric bacteria- blocked from re-entering the gut
only IgG
does phagocytosis and ADCC
IgM an IgG ad IgA
neutralising and complement activation
IgE
activation of mast cells ad basophils
