Ebola

Question 1

size of ebola genome

Answer 1

19kb

Question 2

type of dna

Answer 2

ssRNA

Question 3

how many genes

Answer 3

7

Question 4

where does ebola infect

Answer 4

endothelial cells of blood vessels, monocytes, macrophages, dendritic and liver cells

Question 5

what encodes ebola virus glycoprotein

Answer 5

GP

Question 6

how many forms of glycoprotein (GP

Answer 6

2

Question 7

Trimeric trans-membrane complex targets

Answer 7

Trimeric trans-membrane complex targets virus to
cells via receptor binding - allows virus to introduce
its contents into monocytes/macrophages leading to
inflammatory cytokine dysregulation

Question 8

Soluble dimeric form (sGP)

Answer 8

secreted after infection –

prevents neutrophil activation

Question 9

symptoms

Answer 9

• onset of symptoms abrupt
• fever
• headache
• joint and muscle ache
• sore throat
• red eyes
• weakeness

Question 10

cytokine strom

Answer 10

immune cells get caught one endless loop, releasing extreme levels of cytokines- proteins within cells which cause inflammation and attraction more immune cells

Question 11

septic shock

Answer 11

infected cells detach from blood vessel-> caused by cytokines–> causing massive haemorrhage

Question 12

loss of blood leads to

Answer 12

kidney and liver failure

Question 13

new evidence strongly implicate bats a

Answer 13

reservoir hosts for the ebola virus

Question 14

human-to -human transmission is a

Answer 14

predominant feature of epidemics

Question 15

what is thought to be the origin of ebola

Answer 15

bushmeat activities e..g hunting bats which cause the virus