Cytokines Flashcards
IL-1 is produced by
monocytes and other cells
effect of IL-1
fever, stimulates acute phase protein system , promotes proliferation of Th2 cells
IL-2 produced by
TH0 and TH1
effect of IL-2
T cell growth factor
IL-3 produced by
TH cells, NK cells and mast cells
effect of IL-3
growth factor for hematopoietic cells
IL-4 produced by
TH2: CD4 T cells, was t cells
IL-4 effect
GF for B cells and immunoglobulin secretion, growth and differnetion factor
IFNgamma
TH1 cells
IFNgamme effect
activates NK cells and macrophages, induces expression of MHC class II on many cell types
TGFbeta produced by
lymphocytes, macrophages platelets, mast cells
TGFbeta effect
enhances production of IgA, inhibits activation of monocyte and helps wound healing by activating fibroblasts
TNFa produced by
macrophages and mast cells
TNFa effect
inflammatory response and killing targeted cells by cytotoxic CD8 T cells.
- activates NK cells and macrophages, induces expression of MHC class II on many cell types
- leads to crease entry of IgG and complement and cells to tissue
chemokine CXCL8 is involved in
local inflammatory response, helping attract neutrophils and T cells to the site of infection
