T Cells Flashcards
IFNg starts up what kind of macrophage?
M1
The most important inflammatory cytokine secreted by Th1 cells is…
IFNg
What are M1 macrophages characterized by?
being angry and ingesting any bacteria or invading antigen
What two cytokines are produced by Th17?
IL17, IL 22
What two cytokines induce Th17?
TGFb and IL21
What two cytokines are made by Th2?
IL4 IL13
What type of macrophages do Th2 cells activate?
M2 macrophages
What do M2 macrophages do?
Clear debris and start scar formatin
What type of cells does IL 4 recruit?
Eosinophils
What type of antibody production do Th2 cells stimulate?
IgE
What is the role of follicular helper T cells (Tfh)?
help differentiate the right B cells into plasma cells
What type of antibodies are preferentially induced in the spleen? The gut?
Spleen: IgG
Gut: IgA
What are the molecular markers expressed on the surface of Treg cells?
CD4, CD25
What cytokines are produced by Treg cells?
TGFb and IL10
What do Treg cells do?
downregulate other Th cells, prevent autoimmunity
What pathway is activated when a CTL binds to a FAS (CD95) ligand?
The latent apoptosis pathway is stimulated
What are granzymes and what secretes them?
CTL secrete them
They are lytic granules that have proteases
What help granzymes get into the cell?
perforins
What activates CTL’s? What converts them to memory cells?
IL-2, IL-21
