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IHO Week 3 > Drugs. > Flashcards

Drugs. Flashcards

0
Q

Paclitaxel
Mechanism
CCS/CCNS
Class

A

Promotes spindle formation
CCS
Plant alkyloid

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1
Q

Cisplatin:
Mechanism
CCS/CCNS

A

Crosslink DNA

CCNS

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2
Q

6 Mercaptopurine
Mechanism
CCS/CCNS
Class

A

Guanylyl kinase inhibitor
CCS (S phase)
Purine analogue

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3
Q

Hydroxyurea
Mechanism
CCS/CCNS

A

Ribonucleotide reductase inhibitor

CCS

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4
Q

Vincristine
Mechanism
CCS/CCNS
Class

A

Prevents spindle formation
CCS
Plant alkyloid

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5
Q

Doxorubicin
Mechanism
CCS/CCNS
Class

A

Intercalating agent
CCNS
Anthracycline antibiotic

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6
Q

Cytarabine (Ara-C)
Mechanism
CCS/CCNS
Class

A

Ribonucleotide reductase and DNA polymerase inhibitor
CCS
Pyrimidine analogue

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7
Q

Fludarabine
Mechanism
CCS/CCNS
Class

A

Ribonucleotide reductase and DNA polymerase inhibitor
CCS
Purine analogue

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8
Q

Methotrexate
Mechanism
CCS/CCNS
Class

A

DHFR inhibitor
CCS
Folate analogue

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9
Q

Leucovorin
Mechanism
Class

A

MTX rescue

folate analogue

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10
Q

5-fluorouracil
Mechanism
CCS/CCNS
Class

A

Thymidylate synthase inhibitor
CCS
Pyrimidine

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11
Q

Allopurinol
Mechanism
Class

A

Xanthine oxidase inhibitor

purine analogue

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12
Q

Etoposide
Mechanism
CCS/CCNS
Class

A

TopoII inhibitor and breaks DNA strands
CCS
Plant alkaloid

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13
Q

Mitomycin
Mechanism
CCS/CCNS
Class

A

Crosslinks DNA
CCNS
Antibiotic

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14
Q

Carmustine/Lomustine
Mechanism
CCS/CCNS
Class

A

Crosslinking agent
CCNS
Nitrosureas

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15
Q

Busulfan
Mechanism
CCS/CCNS

A

Crosslinking agent

CCNS

16
Q

Temozoloamide
Mechanism
CCS/CCNS

A

Crosslinks DNA

CCNS

17
Q

Cyclophosphamide
Mechanism
CCS/CCNS
Class

A

Crosslinks DNA
CCNS
Nitrogen mustard

IHO Week 3 (13 decks)

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