DNA Synth Inhibitors

Question 0

This enzyme and its expression is important in resistance to 5-FU

Answer 0

Pyrimidine monophosphate kinase

Question 1

Conversion of UMP to UDP is catalyzed by what enzyme?

Answer 1

Pyrimidine monophosphate kinase

Question 2

One step degradation of thymidine nucleotides is catalyzed by what enzyme?

Answer 2

dihydropyrimidine dehydrogenase

Question 3

An inherited defect in what protein results in increased susceptibility to 5-FU?

Answer 3

Dihydropyrimidine dehydrogenase

Question 4

De novo purine synthesis uses this enzyme in its “committed” step.

Answer 4

Glutamyl Amidotransferase (GPAT)

Question 5

6-MP and 6-TG are competitive inhibitors of what enzyme?

Answer 5

Guanylyl Kinase

Question 6

Guanylyl kinase catalyses what reaction?

Answer 6

GMP->GDP

Question 7

The process of converting purine nucleotides to uric acid to be exreted into urine is catalyzed by what enzyme?

Answer 7

Xanthine oxidase

Question 8

What chemotherapy drugs are degraded by Xanthine Oxidase?

Answer 8

6-TG and 6-MP

Question 9

Xanthine oxidase is inhibited by what drug?

Answer 9

Allopurinol

Question 10

The conversion of ribonucleotides to hydroxyribonucleotides is catalyzed by what enzyme?

Answer 10

Ribonucleotide reductase

Question 11

Cytarabine (ARA-C) and Gemcitabine work by inhibiting enzymes that…

Answer 11

Synthesize DNA

Question 12

The four drugs that are analogs of pyrimidines are…

Answer 12

5-FU
Cepecitabine
ARA-C
Gemcitabine

Question 13

The two purine synthesis inhibitors are…

Answer 13

6-Mercaptopurine

6-Thioguanine

Question 14

What is the supportive drug for purine synthesis inhibition?

Answer 14

Allopurinol

Question 15

This drug is given to inhibit ribonucleotide reductase

Answer 15

Hydroxyurea

Question 16

These two molecules are converted into compounds that compete with and mimic CTP/CDP.

Answer 16

Cytarabine (ARA-C) and Gemicitabine