Myelodysplasia and ALL Flashcards
What cell type might you see increased in Myelodysplastic syndrome?
blast cells
What cell like is the problem in myelodysplastic syndrome?
abnormal stem cells
What does myelodysplastic syndrome look like for RBC’s?
Neutrophils?
Megakaryocytes?
RBC’s: megaloblastic nuclei, fragmentation
Neutrophils: hypogranulation, hyposegmentation
Megakaryocytes: small nonlobulated cells
What are some clinical findings for MDS?
Bone marrow failure
Macrocytic anemia
What age group is ALL most common in?
Children
What is the malignant proliferation in ALL?
lymphoid blasts in bone marrow
T-cell acute lymphoblastic leukemia is diagnosed by these protein markers.
TdT, T cell Antigen
B cell Acute Lymphoblastic Leukemia is characterized by these proteins.
TdT and B cell antigen
Of T cell and B cell ALL, which has the better prognosis?
B cell
T-lymphoblastic leukemia is often in what population?
teenage male
What is the major clinical finding for T lymphoblastic leukemia?
mediastinal mass
What odd chromosomal finding is common to see in B lymphoblastic leukemia?
Philadelphia chromosome
What ages is prognosis best for ALL?
1-10
What odd cellular find makes for best prognosis?
Hyperdiploidy
