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IHO Week 3 > MHC Complex > Flashcards

MHC Complex Flashcards

0
Q

What T cells are able to recognize MHC I?

A

CTL

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1
Q

What T cells are able to recognize MHC II?

A

Th1, Th2, Th17, Tfh, Treg

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2
Q

What notable costimulatory molecules do Dendritic cells produce, along with MHCII?

A

B7 (CD80, CD86)

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3
Q

What activated B cells to produce costimulatory molecules?

A

Antigen binding to antibody

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4
Q

What activates macrophages to express MHC II and costimulatory molecules?

A

phagocytosis

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5
Q

What two characteristics make T cell receptors like antibodies?

A

Constant and variable portion of receptor

Consist of VDJ recombination

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6
Q

What do antibodies do in their differentiation that T cell receptors dont?

A

Somatic hypermutation

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7
Q

When an antigen binds to a T cell, what transmits the signal to the cell to differentiate?

A

CD3

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8
Q

What two signals are needed for a T cell to differentiate?

A

CD3 transmission and Cytokines from a dendritic cell

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9
Q

What signal transduction molecule does CD4 bind to?

A

p56lck

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10
Q

Is CD4 a monomer, dimer, trimer, or tetramer?

A

monomer

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11
Q

Is CD8 a monomer, dimer, trimer, or tetramer?

A

heterodimer or homodimer

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12
Q

What complex of differentiation on T cells binds to B7 on dendritic cells?

A

CD28

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13
Q

After CD28 binds B7, what is the pathway that is activated?

A

MAP kinase

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14
Q

What does CD2 bind?

A

LFA-3

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15
Q

What does LFA-1 bind?

A

ICAM (intracellular adhesion molecule)

16
Q

What does CD45R bind?

A

CD22

17
Q

Which chain (alpha or beta) is encoded by VJC genes?

A

alpha

18
Q

What chain (alpha or beta) is encoded by the VDJC segments?

A

beta

19
Q

What proteins are useful in DNA gene rearrangement during cell maturation?

A

RAG1 and 2

20
Q

If T cells had AID in their gene expression, what would likely be the following pathology?

A

Autoimmunity

21
Q

What molecules are included on MHC class III?

A

Complement, TNFa TNFb, heat shock proteins, etc

22
Q

What peptide does every MHC-I molecule associate with on the cellular surface?

A

Beta2 macroglobulin

23
Q

What are the three genes encoding MHCII?

A

DP encoding DP ab
DQ encoding DQ ab
DR encoding DR ab

24
Q

HLA-B27 individuals are…

A

90x more likely to develop ankylosing spondylitis

and linked to psoriasis, IBS, Reiter’s syndrome.

25
Q

HLA DR2 individuals are…

A

130x more likely to develop narcolepsy

and hay fever, MS, SLE

26
Q

HLA-A3/B14 individuals are…

A

90x more likely to develop hemachromatosis

27
Q

HLA-DQ2/GQ8 are linked to…

A

celiac’s disease

28
Q

HLA-DR3 is linked to

A

Diabetes type 1, Graves’ disease

29
Q

HLA-DR4is linked to…

A

Rheumatoid arthritis and Type I Diabetes

30
Q

HLA-ABC means…

A

CLASS I ALL THE TIME

31
Q

HLA D means…

A

CLASS II

IHO Week 3 (13 decks)

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