General Principles of Malignant Hemopathology

Question 0

What are the two subclasses for leukemia? Lymphoma?

Answer 0

Leukemia: Acute, chronic
Lymphoma: Hodgkin’s and Non-Hodgkin’s

Question 1

Where does malignancy in leukemia start? Lymphoma?

Answer 1

Leukemia: bone marrow
Lymphoma: lymph nodes

Question 2

Lymphoma and Leukemia are both cancers of _______ cells.

Answer 2

Hematopoietic

Question 3

The other class of cancer dealing with plasma cells is called…

Answer 3

Multiple Myeloma

Question 4

Where does multiple myeloma start?

Answer 4

bone marrow

Question 5

What are ways that leukemia/lymphoma are diagnosed?

Answer 5

Clinical presentation
Morphology
Immunophenotyping
Molecular studies
Cytogenetics

Question 6

Where is the most common place to take a bone marrow sample?

Answer 6

Iliac crest

Question 7

As the patient ages, does fat within bone marrow increase or decrease?

Answer 7

Increase. Unlikely to find in infants, likely to be dominant by age 80

Question 8

Acute leukemias are composed of mostly ____ cells

Answer 8

blast

Question 9

Chronic leukemia is mainly composed of _____ cells

Answer 9

Mature

Question 10

The Reed-Sternberg cell is commonly seen in what kind of malignancy?

Answer 10

Hodgkin’s lymphoma

Question 11

If a cellular stain with non-specific esterase reveals many red cells, what lineage is in question?

Answer 11

monocyte lineage ALWAYS.

Question 12

This technique can show translocations like the Philadelphia chromosome

Answer 12

Cytogenetics

Question 13

The specific problematic gene can be isolated in what technique?

Answer 13

PCR