T cell Receptor- MHC interactions Flashcards
Need for T Helper cells and MHC interactions:
Extracellular organisms need 4 T cells to help make a strong — response
Intracellular organisms need a different sort of response, from — CD8 - Cells
There is need to differentiate between the — derived from extracellular and intracellular —
In this way, the appropriate — can be stimulated
Name the 2 cell receptors needed to do this
innate cytotoxic T Antigen sources response TCR MHC
T cell receptor complex:
Found on surface of…
They have similar structures to —
they have 2 chains (alpha + beta) with — and — regions
It has 1 — binding site
It is stabilised by — chains
Alpha & beta chains are both — charged
CD3 polypeptide chains are — charged so hold hold TCR together.
One Ag-MHC binds to the TCR then the — molecules allow — via the — domain
T Lymphocytes Antibodies constant variable antigen CD3 \+vely -vely CD3 signalling cytoplasmic
Major Histocompatibility Complexes:
T cells recognise antigens using the — complex
Ag must be presented by another — for t cell to see it
Ag is presented by self — molecules on — of cell
Both Ag and MHC must be recognised by —
TCR cell MHC surface T cells
CD4 T cells recognise self MHC class II and — anitgens
They help kill — infections such as —
CD8 T Cells recognise self MHC class 1 and — antigens
Directly kill — infections such as —
exogeneous extracellular bacteria endogeneous intracellular viruses
