T and B Cell Activation

Question 0

T/F: antigens for CD4 cells are ingested by dendritic cells whereas antigens for CD8 t cells are produced in the cytoplasm of DCs

Answer 0

True

Question 1

Site of initial activation of T lymphocytes

Answer 1

Peripheral lymphoid organs

Question 2

Costimulators recognized by the CD28 receptor on naive T cells

Answer 2

B7 molecules

Question 3

Activate APCs, making them more potent by enhancement of B7 molecules and secretion of cytokines

Answer 3

CD40, CD40L

Question 4

Master regulator of TH1 differentiation

Answer 4

Tbet

Question 5

Master regulator of Th2 differentiation

Answer 5

GATA-3

Question 6

Th1 differentiation pathway

Answer 6

IL12, IFNy – Tbet, STAT1, STAT4

Question 7

Differentiation pathway for Th2

Answer 7

IL4 – STAT6 – GATA-3

Question 8

Inhibits th17 differentiation

Answer 8

IL4, IFNy

Question 9

Increased in memory T cells, allowing them to achieve a quiescent state

Answer 9

Anti-apoptotic proteins

Question 10

Difference between central and effector memory T cells

Answer 10

Central:expresses CCR-7 and L-selectin, located in lymph nodes for proliferative response

Effector: located in peripheral sites, produce effector cytokines

Question 11

______ leads to contraction of T cell response

Answer 11

Elimination of antigens

Question 12

Anti-apoptotic proteins

Answer 12

Bcl-2, bcl-XI

Question 13

Leads to enhanced BCR signaling for proliferation and differentiation of B cells

Answer 13

Activation of Toll-like receptors

Question 14

Epitope recognized by B cells

Answer 14

Surface/conformational epitope

Question 15

Epitope recognized by Th, binds to class II MHC

Answer 15

Internal linear peptide epitope

Question 16

Small chemicals bound by antibodies but are not by themselves immunogenic

Answer 16

Haptens

Question 17

If haptens are coupled to protein carriers, they are able to induce an antibody response

Answer 17

Hapten-Carrier effect

Question 18

Leads to the production of antibodies with heavy chains of different classes

Answer 18

Isotype switching

Question 19

T/F: some extrafollicular B cell foci form in T cell zones

Answer 19

true

Question 20

Structures which form within folicles, sites of extensive isotype switching

Answer 20

Germinal Centers

Question 21

Process that leads to increased affinity of antibodies to a particular antigen as a T-dependent humoral response progresses

Answer 21

Affinity maturation

Question 22

Morphologically-distinct, terminally-differentiated B cells committed to abundant antibody production

Answer 22

Plasma Cells

Question 23

Plasma cells generated during t-dependent germinal center response

Answer 23

Long-lived plasma cells

Question 24

Mechanism by which humoral immune responses are downregulated when enough antibody has been produced

Answer 24

Antibody feedback