Innate and Adaptive Immune System

Question 0

Invariant structures shared by entire classes of microorganisms fundamental to their integrity, survival, and pathogenicity

Answer 0

Pathogen-associated molecular patterns (PAMPs)

Question 1

Receptors of innate immunity that recognize pathogen-associated molecular patterns

Answer 1

Pattern recognition receptors

Question 2

Recognise PAMPs, causing a signaling cascade

Answer 2

Toll like receptors

Question 3

Steps of leukocyte recruitment

Answer 3

Rolling - selectin-mediated attraction of leukocytes to areas of infection

Binding - integrins allow leukocytes to attach to basement membrane

Transmigration - leukocytes leave the blood vessel

Question 4

Generates ROS that is used in immune defense

Answer 4

NADPH phagosome oxidase

Question 5

Process wherein oxygen consumed by ROS production is provided by increasing the O2 uptake of the cell

Answer 5

Respiratory Burst

Question 6

Pathway which leads to the formation of the membrane attack complex

Answer 6

Mannose Binding Pathway

Question 7

Recognizes phosphatidylcholine on microbial surface, binds to them, and promotes phagocytic attack

Answer 7

C-reactive protein (CRP)

Question 8

Recognizes mannose containing molecular patterns on microbes, directs complement attack

Answer 8

Mannose-binding lectin

Question 9

Proteins that kill certain bacteria directly by disrupting lipid membranes or aggregating bacteria

Answer 9

Collectins

Question 10

_____ and _____ are antimicrobial peptides of the physical barriers of the innate immune system

Answer 10

Defensins, cathelicidins

Question 11

Lymphocytes found in the epithelial layer of mammalian mucosal linings

Answer 11

Intraepithelial T cells

Question 12

Most abundant WBC

Answer 12

Neutrophils

Question 13

Directly kill distressed or infected cells

Answer 13

Natural Killer cells