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Hema-Immuno > Blood Type Origins > Flashcards

Blood Type Origins Flashcards

0
Q

Many genes that encode for the same phenotype

A

Polygeny

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1
Q

Gene that has many alleles across a population

A

Polymorphism

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2
Q

Phenomenon which activates the complement cascade

A

Binding of antibodies on antigens of foreign bodies

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3
Q

System made up of distinct plasma proteins that react with one another to make pathogens susceptible to phagocytosis

A

Complement system

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4
Q

Precursor for all ABO blood types

A

H antigen

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5
Q

Locus of FUT1 gene encoding fucosyltransferase

A

Chromosome 19

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6
Q

ABO locus

A

Chromosome 9

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7
Q

Enzyme associated with A antigen

A

Alpha-1,3-N-acetylgalactosamine transferase

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8
Q

Enzyme associated with B antigen

A

Alpha-1,3-galactosyl transferase

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9
Q

Allele which lacks a guanine nucleotide at position 261 of exon 6

A

i (for type O)

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10
Q

Site of attachment for ABO antigens

A

RBC membrane glycoproteins

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11
Q

Persons who have ABO antigens in other body fluids except for CSF

A

Secretors

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12
Q

Antigen associated with Rh blood typing

A

D antigen

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13
Q

T/F: ABO antigens are glycoproteins whereas Rh antigens are proteins

A

True

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14
Q

Protein which gives rise to D antigen

A

RHO protein

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15
Q

Protein which gives rise to C/c and E/e antigens

A

RHCE protein

16
Q

Function of RHD and RHCE membrane multipass proteins

A

Transport of ammonium across RBC membrane

17
Q

Immune response of an immunocompetent individual to foreign antigens of the same species

A

Alloimmunization

18
Q

Treatment for erythroblastosis fetalis

A

RhoGAM

19
Q

Genes which encode for antigen proteins located on the surface of white blood cells

A

Human leukocyte antigens/major histocompatibility complexes

Specific to humans ang HLA

20
Q

MHC presented to cytotoxic T cell

A

MHC I

21
Q

MHC detected by helper T cells

A

MHC class II

Hema-Immuno (12 decks)

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