Immunologic Tolerance

Question 0

Antigens which generate immunity

Answer 0

Immunogens

Question 1

Antigens which induce tolerance

Answer 1

Toleregens

Question 2

Unresponsiveness to an antigen induced by previous exposure to the antigen

Answer 2

Immunological Tolerance

Question 3

Functional unresponsiveness

Answer 3

Anergy

Question 4

Therapy to stop or prevent the autoimmune disease while leaving the body’s disease-fighting abilities intact

Answer 4

Immune tolerance therapy

Question 5

Central vs peripheral tolerance

Answer 5

Central: induced in generative lymphoid organs
Peripheral: physiological unresponsiveness to self antigens; recognition of antigens without costimulators

Question 6

Deletion: cells with ____ avidity for self-antigens are deleted by apoptosis

Answer 6

High

Question 7

Transcription factor which promotes the expression of selected tissue antigens in the thymus

Answer 7

AIRE: autoimmune regulator protein

Question 8

Autoimmune disorder related to deletion, mutations in AIRE gene

Answer 8

Autoimmune polydenocrine syndrome

Question 9

Inhibitory receptor active in anergy

Answer 9

Cd28

Question 10

Activated transcription factor in the expression of CD4 and CD25 for the maintenance of immune tolerance

Answer 10

FoxP3

Question 11

Inhibits t cell activation and t cell effector functions

Answer 11

IL-10

Question 12

Proapoptotic factor of the Bcl-2 family

Answer 12

Bim

Question 13

Genes that cause B cells to Acquire new specificity

Answer 13

RAG1, RAG2