Antigen Processing

Question 0

Initially immature cells that migrate to T-cell zone of the lymph node once they come into contact with antigens

Answer 0

Dermal dendritic cells

Question 1

Displayed by APCs for T-cell recognition

Answer 1

Peptide-MHC complexes

Question 2

Modes by which professional APCs internalize antigens

Answer 2

Phagocytosis

Receptor-mediated endocytosis

Question 3

Phenomenon wherein the epitope that is processed and presented is one that causes the best immune response

Answer 3

Immunodominance

Question 4

T/F: B cells recognize amino acid sequences whereas B-cells recognize conformational determinants

Answer 4

False

T cells - amino acids
B-cells - conformational determinants

Question 5

Property of T-cells that restricts them to recognizing antigens bound to self-APC

Answer 5

Self-MHC restriction

Question 6

MHC molecules bind ______

Answer 6

Peptides

Question 7

Site where MHC II is synthesized

Answer 7

ER

Question 8

Cause enzymatic breakdown of internalized proteins

Answer 8

Cathepsins

Question 9

_____ controls the dissociation of CLIP and facilitates the binding of Antigenic peptides

Answer 9

HLA-DM

Question 10

Enzymes associated with the MHC I pathway

Answer 10

Transporter associated with antigen processing (TAP) - facilitates entry
ER resident aminopeptidase - trims peptides