Systemic Lupus Erythematosus Flashcards
What is SLE?
a multisystemic autoimmune disease where ANA and anti-double stranded DNA antibodies attack soft tissue inflammation and damage
Who is lupus more common in?
Young, black women
What % of patients have a 1st or 2nd degree relative with SLE?
10%
What symptoms are present in SLE?
Butterfly rash, weight loss, fever, fatigue, joint pain, mouth ulcers
What sign can be present?
Correctable ulnar deviation
How many diagnostic criteria does a patient need to meet?
4 or more with at least 1 clinical and at least 1 laboratory
What happens to complement levels?
C3 and C4 decrease and their degradation products C3d and C4d increase
What are CRP and ESR?
Increased ESR but normal CRP
What are some differential diagnoses?
Serositis, arthritis, infection
How do you manage SLE?
Ibuprofen, cyclophosphamide, hydroxychloroquine, prednisolone, methotrexate
How might you manage lupus nephritis?
More intensive immunosuppression, BP control, renal replacement therapy if disease progresses
What are some complications of SLE?
Cardiac, lungs, kidney
What does antiphospholipid syndrome cause?
CLOTS Coagulation defect Livedo reticularis Obstetric problems Thrombocytopenia
How is antiphospholipid syndrome diagnosed?
Persistent antiphospholipid antibodies and clinical features
How do you treat antiphospholipid syndrome?
Anticoagulants
