Sympathetic Flashcards
Direct acting Sympathomimetic
Epinephrine b>a Norepinephrine a>b Phenylephrine alpha1 Methoxamine alpha1 Midodrine alpha1 for orthostatic hypotension Isoproterenol b1=b2 >>a Dopamine
Effect of dopamine depending on the dose
Low dose b1
High dose a1
Vasodilation at the juxtaglomerular cells-renal vascular bed
Selective Beta 1 agonist
!!!Dobutamine
Dopamine in low dose
Ibopamine
Selective beta 2 receptor agonist
Salbutamol Terbutaline also to suppress premature labor Albuterol Metaproterenol Ritodrine to suppress premature labor
Alpha 2 receptor agonist
Clonidine Guanfacine Guanabenz Monoxidine Rilmenidine Methyldopa
Indirect acting sympathomimetics
Amphetamine
Tyramine
Ephedrine
Re uptake inhibitors
Cocaine
Tricyclic antidepressants
Non selective alpha antagonist
Phenoxybenzamine
Phentolamine
Selective alpha1 antagonist
Prazosin
terazosin
doxazosin
tamsulosin alfuzosin : only on alpha 1a bladder ureter so only for treatment of benign prostate hyperplasia
selective beta 1 blockers
!!! A to M blockers Atenolol Betaxolol Acebutolol Esmolol shortest half life-10min Metoprolol Bisoprolol Celiprolol Nebivolol 10-30h
Beta and alpha 1 antagonist
Labetalol
Carvedilol
Bucindolol
Non selective beta blockers
Propranolol Pindolol Oxprenolol Alprenolol Nadolol Carteolol Carvedilol Labetalol Penbutolol Sotalol Timolol
Beta blockers with ISA
Pindolol Acebutolol Carteolol Oxprenolol Penbutolol Alprenolol Celiprolol
B blockers with high solubility
Propranolol
Penbutolol
B blockers with the lowest lipid solubility
Atenolol
Sotalol
Acebutolol