Compartments of drug distribution

Question 1

TOTAL BODY WATER

Answer 1

Small, water soluble molecules, eg. ethanol, phenytoin, diazepam (0.6 l/kg)

Question 2

EXTRACELLULAR WATER

Answer 2

Bigger, water soluble molecules eg.gentamycin, tubocurare (0.2 l/kg)

Question 3

Blood/ Plasma

Answer 3

(0.08L/KG) and (0.04 l/kg) drugs bound in plasma protein and very big molecules (heparin, insulin, warfarin)

Question 4

Fat

Answer 4

Highly lipidsoluble molecules e.g. DDT, thiopental

0.2-0.35 l/kg

Question 5

Bone

Answer 5

(0.07 l/kg): ions, e.g. lead, fluor, tetracyclin