Antiepileptics drugs

Question 1

Sodium channel blocker

Answer 1

carbamazepine
eslicarbazepine
lacosamide/ rufinamide
oxcarbazepine
phenytoin and fosphenytoin

Question 2

inhibition of T-type calcium channels + absence seizures

Answer 2

ethosuximide

Question 3

open voltage gated M type potassium channels

Answer 3

Ezogabine

Question 4

Large spectrum: blocking of voltage dependant sodium channels, competing with glycine on NMDA, blocking calcium channel, increase GABA

Answer 4

felbamate

Question 5

Increase glutamate by blocking N-type presynaptic calcium channel

Answer 5

gabapentin

pregabalin

Question 6

Broad spectrum: block calcium and sodium channel

Answer 6

Lamotrigine

Question 7

inhibit N-type calcium channel and binds to SV2A

Answer 7

levetiracetam

Question 8

Drugs acting on GABA system

Answer 8

phenobarbital
primidone
vigabatrin (irreversible GABA-T inhibitor)
Tiagabine (inhibit GABA reuptake))

Question 9

blocks sodium channel, L-type calcium channel, carbonic anhydrase inhibitor and inhibit glutamate NMDA sites

Answer 9

Topiramate

Question 10

sodium channel blocker
T-type calcium blocker
block GABA-T

Answer 10

valproic acid and divalproex

Question 11

block sodium channel and T-type calcium channel

carboanhydrase inhibition

Answer 11

zonisamide