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Pharmacology > Cancer > Flashcards

Cancer Flashcards

1
Q

Antifolates drugs

A

Methotrexate
Raltitrexed
Pemetrexed

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2
Q

Pyrimidine analogs

A 
5-fluorouracil
Tegafur 
Capecitabine
Trifluridine
Tipiracil
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3
Q

Purine analogs

A

6-mercaptopurine
6-thioguanine
Fludarabine
Nelarabine

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4
Q

Deoxycytidine analogues

A

Gemcitidine

Cytarabine

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5
Q

Inhibition of RNA reductase

A

Hydroxycarbamide

Hydroxyurea

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6
Q

Alkylating agents nitrogen mustard derivatives

A

Cyclophosphamide
Ifosfamide
Melphalon
Thiotepa

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7
Q

Alkylating agents Nitrosurea

A

Carmustine

Lomustine

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8
Q

Alkylting drugs platinium analogs

A

Cisplatin
Carboplastin
Oxaliplatin

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9
Q

Other dna alkylating for glioma

A

Busulfan
Temozolomide
Dacarbazine
Procarbazine

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10
Q

Antibiotics

A

Bleomycin (in G2 phase)

Actinomycin D

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11
Q

Topoisomerase I inhibitors

A

Irinotecan

Topotecan

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12
Q

Topoisomerase II Anthracyclines

A

Doxorubicin
Daunorubicin
Epirubicin
Idarubicin

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13
Q

Topoisomerase II inhibitors Antracenediones

A

Mitoxantrone

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14
Q

Topoisomerase II inhibitors Epidophyllotoxins

A

Etoposide

Teniposide

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15
Q

Taxanes

A

Paclitaxel
Docetaxel

They inhibit the depolymerization

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16
Q

Vinca alkaloids !!! Pediatrics

A

Vincristine

Vinblastine

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17
Q

Others

A

Estramustine phosphate
Mitotane
Bexarotene

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18
Q

Glucocorticoids for cancer

A

Prednisolone
Methylprednisolone
Dexamethasone

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19
Q

Progestins

A

Medroxyprogesterone

Megestrol

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20
Q

Anti estrogen

A

Tamoxifen
Toremifene
Fulvestrant

21
Q

Aromatase inhibitors

A

Anastrozole

Exemestane

22
Q

Antiandrogen

A

Flutamide

Bicalutamide

23
Q

LH-RH analogs

A

Buserelin
Goserelin
Leuprolide

24
Q

Gn-RH inhibitors

A

Degarelix

25
Q

Carcinoid tumor drug

A

Octreotide

26
Q

MTOR inhibitors

A

Everolimus

Temsirolimus

27
Q

Receptor tyrosine kinase inhibit ABL/Ckit/PDGFR

A

Imatinib

28
Q

Receptor tyrosine kinase HER2 + EGFR antagonist

A

Lapatinib

29
Q

Receptor tyrosine kinase EGFR selective antagonist

A

Afatinib
Gefitinib
Erlotinib

30
Q

Receptor tyrosine kinase Bruton tyrosine kinase inhibitor

A

Ibrutinib

31
Q

Receptor tyrosine kinase multiple GFR antagonist

A

Sorafenib

Sunitinib

32
Q

Receptor tyrosine kinase selective VEGFR 1,2,3 antagonist

A

Axitinib

33
Q

Multiple tyrosine kinase inhibitors

A

Regorafenib

34
Q

Receptor tyrosine kinase anaplastic lymphoma kinase inhibitor

A

Crizotinib

Certinib

35
Q

Receptor tyrosine kinase BRAF kinase inhibitors

A

Vemurafenib

Dabrafenib

36
Q

Receptor tyrosine kinase MAP kinase inhibitor

A

Trametinib

37
Q

Proteasome inhibitor

A

Bortezomib

38
Q

BCL-2 protein inhibitor

A

Venetoclax

39
Q

Retinoids

A

Tretinoin
Alitretinoin
Bexaroten

40
Q

Monoclonal antibody against CD20

A

Rituximab

41
Q

Anti -EGFR mab

A

Cetuximab

Panitumumab

42
Q

Anti HER-2

A

Trastuzumab + emtansin (MT inhibitor)

43
Q

Anti-IL-2

A

Aldesleukin

44
Q

2 binding sites: CD3 and CD19

A

Blinatumomab

45
Q

3 binding sites: CD3, macrophages and EpCAM

A

Catamaxomab

46
Q

Binds CTLA-4

A

Ipilimumab

47
Q

Binds PD-1

A

Pembrolizumab

48
Q

Human IgG4 mab which binds PD-1

A

Nivolumab

49
Q

Anti VEGF-A antibody

A

Bevacizumab

Pharmacology (36 decks)

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