Sunetra Gupta

Question 1

HepA

Answer 1

• Picornavirus
• RNA capsid, 5’Vpg
• endemic: 90% infection <10yrs
• 70% jaundice
• immunisations

Question 1

HepB

Answer 1

• Hepadinovirus
• chronic infection (cirrhosis, hepatocellular carcinoma)
• DNA, DNAPS
• 80% asymptomatic
• 20% acute infection
• 1-3% fulminant hepaptisis
• 1-8% chronic carriers
• 95% < 6yrs: undetectable selection
• pre and post immunisation, blood donor screening

Question 2

HepC

Answer 2

• chronic
• 3-4mill
• 3% globe
• blood donor screening

Question 3

HepD

Answer 3

• bilayer, RNA
• chronic
• pre and post immunisation

Question 4

symptoms of Hep

Answer 4

abdominal discomfort, jaundice, fatigue, fever, appetite loss, nausea

Question 5

Hep immunity

Answer 5

1) inhibits NKs
2) epitope diversity
3) strain diversity
4) Ab neutralisation

Question 6

HBV life cycle

Answer 6

1) virions undero nuclear localisation
2) integrate cccDNA
3) transcribe m and pgRNA
4) form nucleocapsid with RNA, RNAP and core antigens
5) budding

Question 7

Why did omicron come to prevalence?

Answer 7

• low cross-immunity because of the 5014.V2 immune escape; [serial strain dynamics], take over the system aided by greater transmissibility of Glycogen at 614

Question 8

R0 = lifespan

Answer 8

/ age of first infection