Meiosis

Question 1

SC formation

Answer 1

• DSB(in)dependent synapsis
• structural array
• “blobs” recombination sites
• stabilises homolog interactions
• promotes crossing over

Question 2

transverse filaments

Answer 2

Zip1/Scp1

Question 3

chromosomal movement driven by

Answer 3

microtubules up and down the cell

Question 4

Holliday junctions

Answer 4

1. Spo11 creates ds break
2. resection creates 3’OH overhand (Dmc1, Rad51)
3. D loop invades homolog
4. polymerised
5. chromatid captured by extruded sequence

Question 5

Sgo1, Sgo2

Answer 5

• 30-130kDa
• PP2A phosphatase