Structural Lower GI Flashcards
What is diverticulosis?
The presence of diverticula
What is diverticular disease?
Diverticular which are symptomatic
What is diverticulitis?
Inflammation of a diverticulum
Why does a low fibre diet lead to diverticular disease?
The colon works harder to move faeces.
This increases the pressure in the lumen
Diverticula form as the mucosa herniates through the muscle layer to form an outpouching
Where are diverticula most common?
Sigmoid colon
Who tend to present with diverticular disease?
Those with a western lifestyle - processed foods with low fibre diet
Older patients
What are the signs and symptoms of diverticular disease?
Change to normal bowel habit
Left iliac fossa colic
What are the signs and symptoms of diverticulitis?
Severe pain in LIF
Fever
Tachycardia
Tenderness and guarding of the left side of the abdomen on examination
What investigations can discover diverticula?
Colonoscopy or sigmoidoscopy
Barium enema
What investigations can help diagnose diverticulosis?
Increased ESR/CRP
CT is investigation of choice
What are the complications of diverticular disease?
Perforation
Haemorrhage
Fistula
Stricture
What can a perforation of a diverticulum cause?
Peritonitis
Abscess
What is the classification system for acute diverticulitis?
Hinchey classification
What are the four stages of the Hinchey classification of acute diverticulitis?
- Pericolic abscess
- Pelvic abscess
- Purulent peritonitis
- Faecal peritonitis
What is the treatment of diverticular disease?
Balanced diet with enough fibre
Analgesia and possibly bulking laxative for symptoms
What is done for uncomplicated diverticulitis?
Watchful waiting
Analgesia if necessary
Antibiotics if suspected infection
IV fluids, IV antibiotics, bowel rest
What is done for complicated diverticulitis?
Percutaneous drainage of large abscess
Laparoscopic peritoneal lavage and drainage
Hartmann’s procedure
Primary resection
What is Hartmann’s procedure?
Remove the sigmoid colon and use a colostomy
What are the types of colonic polyps?
Adenoma
Serrated
Inflammatory
Hamartomatous
What are the most common colonic polyps?
Adenomas
When do inflammatory polyps occur?
IBD
When fo hamartomatous polyps occur?
Peutz-Jeghers syndrome
Which mutation causes familial adenomatous polyposis?
Mutation in the APC tumour suppressor gene
What is the % risk of colon cancer for patients with FAP?
Almost 100%
Describe the polyps Lynch syndrome causes?
Adenomas
Right-sided
Not always colonic, can be gastric, endometrial
Which mutation causes Lynch syndrome?
DNA mismatch
What are the characteristics of Peutz-Jeghers syndrome?
Hyperpigmentation
Hamartomatous polyps
What are the risk factors for colonic polyps?
Patients with inherited conditions
IBD
Smoking and alcohol
Older age
What are the symptoms of colonic polyps?
Usually asymptomatic
Rectal bleeding causing anaemia
Mucus in stool
Diarrhoea and constipation
What investigations can help diagnose colonic polyps?
Family history
Genetic testing
Colonoscopy
Biopsy