Still's Disease

Question 1

features of still’s disease?

Answer 1

(poly)arthralgia
rash - salmon-pink, maculopapular
pyrexia (late afternoon/early evening daily + worsened joint symptoms and rash)
lymphadenopathy

high serum ferritin

Question 2

epidemiology of still’s disease?

Answer 2

bimodal age distribution - 15-25y and 35-46y

Question 3

ab a/w still’s disease?

Answer 3

rf and ana negative

Question 4

what criteria are used to diagnose still’s?

Answer 4

yamaguchi criteria

Question 5

mx of still’s disease?

Answer 5

nsaids - first-line (for fever, joint pain, serositis)
trial for at least a week

steroids (symptom control)

methotrexate/ant-IL-1/anti-TNF if still refractory

Question 6

example of anti-IL1 used to treat still’s flares?

Answer 6

anakinra