Antiphospholipid Syndrome

Question 1

what is the coag profile of antiphospholipid syndrome?

Answer 1

rise in aptt (paradoxical!)

due to ex vivo reaction of lupus anticoagulant ab with phospholipids involved in coagulation cascade

Question 2

associations w antiphospholipid syndrome

Answer 2

sle
other AID
lymphoproliferative disorders
phenothiazines - rare

Question 3

mx of antiphospholipid syndrome

Answer 3

primary thrombophylaxis: low-dose aspirin

secondary thrombophylaxis:
- initial VTE events - lifelong warfarin (target INR 2-3); if alr taking then consider low-dose aspirin (target INR 3-4)
- arterial thrombosis - lifelong warfarin (target INR 2-3)