Psoriatic Arthritis Flashcards

1
Q

what is psoriatic arthritis?

A

INFLAMMATORY arthritis
a/w psoriasis
seronegative spondyloarthropathies

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2
Q

psoriatic arthritis correlates poorly with?

A

cutaneous psoriasis

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3
Q

psoriatic arthritis precedes?

A

development of skin lesions

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4
Q

sex difference in psoriatic arthritis?

A

equal

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5
Q

presentation pattern of psoriatic arthritis?

A

symmetric polyarthritis (most common type) - dip and pip
asymmetric oligoarthritis (hands and feet typically) - dip and pip
sacroilitis
dip joint disease
arthritis mutilans

psoriatic skin lesions
periarticular disease
nail changes

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6
Q

what is arthritis mutilans?

A

severe deformity fingers/hand
‘telescoping fingers’

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7
Q

what periarticular disease can be seen in psoriatic arthritis?

A

tenosynovitis and soft tissue inflammation resulting in
- enthesitis
- tenosynovitis typically of flexor tendons of hands
- dactylitis - diffuse swelling of finger or toe

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8
Q

what’s enthesitis

A

inflammation at site of tendon/ligament insertion (e.g. achilles tendonitis, plantar fasciitis)

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9
Q

ix of psoriatic arth?

A

xray - unusual combination of erosive changes + bone formation
periostitis
pencil in cup appearance

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10
Q

mx of psoriatic arth?

A

similar to RA but differences are:

-mild peripheral arthritis/axial disease: just an NSAID rather than DMARD
- mAb - ustekinumab, secukinumab

better prognosis than RA

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11
Q

moa of ustekinumab

A

targets il-12 and il-23

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12
Q

moa of secukinumab

A

targets il-17

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13
Q

what is onycholysis?

A

separation of nail plate from nailbed
commonly a/w psoriasis

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14
Q

what is dactylitis?

A

inflammation of a digit

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15
Q

what are causes of dactylitis?

A

spondyloarthritis: e.g. Psoriatic and reactive arthritis
sickle-cell disease
other rare causes include tuberculosis, sarcoidosis and syphilis

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