ANCA-Associated Vasculitis

Question 1

what are the anca-assoc vasulitides?

Answer 1

small-vessel
granulomatosis with polyangiitis
eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
microscopic polyangiitis

Question 2

another term for Churg-Strauss syndrome?

Answer 2

eosinophilic granulomatosis with polyangiitis

Question 3

renal impairment in anca-associated vasculitis?

Answer 3

raised creatinine, haematuria and proteinuria

caused by immune complex glomerulonephritis

Question 4

resp symptoms in anca-associated vasculitis?

Answer 4

dyspnoea
haemoptysis

Question 5

systemic symptoms in anca-associated vasculitis?

Answer 5

fatigue
weight loss
fever

Question 6

dermatological symptoms in anca-associated vasculitis?

Answer 6

vasculitic rash - only present in a minority of pt

Question 7

ENT symptoms in in anca-associated vasculitis?

Answer 7

sinusitis

Question 8

first-line ix in anca-associated vasculitis?

Answer 8

urinalysis - haematuria, proteinuria

bloods:
- urea and creatinine - renal impairment
- fbc - normocytic anaemia, thrombocytosis
- crp - raised
- anca testing

cxr

Question 9

what does cxr show in anca-associated vasculitis?

Answer 9

nodular, fibrotic or infiltrative lesions

Question 10

two many ANCA subtypes?

Answer 10

cytoplasmic or perinuclear

Question 11

cANCA a/w?

Answer 11

granulomatosis with polyangiitis

Question 12

pANCA a/w?

Answer 12

eosinophilic granulomatosis with polyangiitis
UC
PSC
anti-GBM
CD (only 20%)

Question 13

levels of which ANCA subtype can be used to monitor disease activity?

Answer 13

cANCA

Question 14

what does cANCA target?

Answer 14

serine proteinase 3

Question 15

what does pANCA target?

Answer 15

myeloperoxidase

Question 16

mx for anca-associated vasculitis?

Answer 16

immunosuppressive therapy