Steroids

Question 1

Aldosterone

Answer 1

Made in Zona glomerulosa

Question 2

Cortisol

Answer 2

Made in Zona Fasciculara and reticularis
ACTH neg feedback loop
90% bound in plasma via CBG or Transcortin

Question 3

Dexmethasone

Answer 3

glucocorticoid

Question 4

Prednisolone

Answer 4

glucocorticoid

Question 5

Fludrocortisone

Answer 5

glucocorticoid

Question 6

Metyrapone

Answer 6

Blocks 11-Beta Hydroxylation
This produces a build up of 11-desoxycortisol (no feedback to ACTH) and 17-hydroxycorticoids
used as a diagnostic test for adrenal insufficiency
No build up indicates insufficiency

Question 7

Mifepristone

Answer 7

competitive Antagonist of progesterone receptor and GC receptor
terminates pregnancy and treats Cushing Disease

Question 8

Spironolactone

Eplerenone

Answer 8

competitive antagonist of MC receptor
Diuretic
Tx- hypertension

Question 9

Drospirenone

Answer 9

progesterone receptor agonist
1. with estrogen, suppress ovulation
2. with estrogen. hormone replacement for post-menopausal women
Mineralocorticoid receptor antagonist
1. diuretic
2. antagonizes salt retaining effect of estrogen
Androgen antagonist