Smooth Muscle Flashcards
Nitroglycerin
Relaxation of vascular smooth muscle (venous Dominant) Decreases Preload NO and cGMP Tx heart failure side effect- hypotension
Nitroprusside
Relaxation of vascular smooth muscle decrease preload and afterload Release of NO Tx-hypertesion emergency side effect- hypotension
Hydralazine
Used with isosorbide dinatrate (decreases preload)
Effects Arterial Circulation
Decreases After load
tx- severe hypertension and hypertension emergency
side effect- hypotension
Minoxidil
K ATP Channel Opener Arterial Circulation tx- severe hypertension Side effect-fluid retention so use with diuretic Used for hair growth
Diazoxide
K channel opener
tx-hypogycemia and hypertension emergencies
Ca Channel Blockers
Works on Ca receptors
Arterial circulation
Milrinone
Phosphodieterase inhibitor PDE3
effects intracellular signaling
Dialates BV and increases heart contractility
Tx Heart failure
Inamrinone
Phosphodieterase inhibitor PDE3
effects intracellular signaling
Dialates BV and increases heart contractility
Tx Heart failure
Cilostazol
Phosphodieterase inhibitor PDE3
effects intracellular signaling
Dialates BV and increases heart contractility
Tx Heart failure
Sildenafil
Phosphodieterase inhibitor PDE5
effects intracellular signaling
Dialates BV
Tx erectile dysfunction
Tadalafil
Phosphodieterase inhibitor PDE5
effects intracellular signaling
Dialates BV
Tx erectile dysfunction
ACE Inhibitors
Block ACE thus inhibits ANG II production
Arterial dominant
Vasodilation
Also blocks inactivation of bradykinin (vasodilator)
Fenoldopam
Acts on DA1 receptor
increases renal BF and Na excretion
Tx-hypertensive crisis
Prazosin
Alpha adrenergic blocker
Vasodialator
tx BPH
Albuterol
B2 adrenergic agonist
