Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Block 2 > Anti-coagulants etc > Flashcards

Anti-coagulants etc Flashcards

1
Q

Heparin

A

Catalyzes anti-thombin causing an inactivation of thrombin and Xa etc
Parental administration (IV or IM)
Does NOT cross the placenta (Pregnancy is OKAY)
Half Life is Dose dependent
Does NOT effect synthesis of clotting factors
Does NOT lyse the existing clot
DOES prevent further clot formation
DOES prevent the further extension of the clot
Monitor via aPTT
Adverse Rxn
Bleeding or Thrombocytopenia
Used for DVT, Pulmonary embolism, coronary angioplasy or stent replacement. cardiopulmonary bypass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Low Molecular Weight Heparins

A

Catalyzes anti-thrombin causing inactivation of Xa
Does not effect thrombin
Renal Clearance
Used for DVT, hip replacement surgery, unstable angina and MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Enoxaparin

A

Catalyzes anti-thrombin causing inactivation of Xa
Does not effect thrombin
Renal Clearance
Used for DVT, hip replacement surgery, unstable angina and MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Dalteparin

A

Catalyzes anti-thrombin causing inactivation of Xa
Does not effect thrombin
Renal Clearance
Used for DVT, hip replacement surgery, unstable angina and MI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Lepirudin

A 
Parenteral Direct Thrombin Inhibitor
IV admin
blocks substrate binding to thrombin
Renal Clearance
Used as an alternative to Heparin when heparin-induced thrombocytopenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bivalirudin

A 
Parenteral Direct Thrombin Inhibitor
IV admin
blocks substrate binding to thrombin
Renal Clearance
Used as an alternative to Heparin when heparin-induced thrombocytopenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fondaparinux

A 
Parenteral Direct Xa Inhibitor
SQ admin
causes Antithrombin to bind to Xa
Renal Clearance
Used for DVT, Pulmonary embolism
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Protamin Sulfate

A

Heparin Antagonist
Positive charge
Adverse effects- Anaphylactic reaction, Pulmonary hypertension
Used for Heparin Overdoses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Warfarin

A

Oral Anticoagulant
analog to Vitamin K that inhibits (competitive) VKORC1
Vit K then can not be recycled to assist in making functional clotting factors
Monitor with Prothrombin time and INR
Effects are delayed
Metabolized by CYP2C9
Adverse Rxn- Purple toe, skin necrosis
can overcome with Vit K
Used for- long term venous thromboembolic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dabigatran

A

Oral anticoagulant
Blocks active site of thrombin
inhibits fibrin bound and free thrombin
Rapid onset
Renal clearance
P-glycoprotien pumps into intestinal lumen
Used for- nonvalvular atrial fibrillation and knee or hip replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Rivaroxaban

A

Oral anticoagulant
Direct Xa inhibitor- binds to S1 and S4 pockets
decreases amplification of thrombin
inhibits Free Xa and Xa in the prothrombinase complex
P-glycoprotien pump
Renal clearance
Uses- nonvalvular atrial fibrillation and hip or knee replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tissue Plasminogen Activating Factor (t-PA)

A

Plasminogen activator to Plasmin

Plasmin degrades clotting factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Alteplase

A

Plasminogen activator to Plasmin
Clot buster
Plasmin degrades Fibrin
Activates bound plasminogen more readily than free
IV administration and short half life
Complications- Hemorrhage
Used for- Acute MI, Pulmonary embolism/DVT, Stroke (within 3 hours)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Aminocaproic Acid

A

Inhibitor of Fibrinolysis

treat urinary tract bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Aspirin

A

You know this

COX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dipyridamole

A 
Anti-platelet and vasodilator
Phosphodiesterase inhibitor
PDE3 and PDE5
increase cAMP which inhibits aggregation of platelets
Used for prosthetic heart valves
17
Q

Ticlopidine

A

P2Y1/P2Y12 receptor inhibits ADP-induced platelet aggregation
Oral
irreversable
Neutropenia

18
Q

Clopidogrel

A

P2Y1/P2Y12 receptor inhibits ADP-induced platelet aggregation
Oral
irreversable
CYP2C19
Used for- Angina, MI, peripgeral arterial disease

19
Q

Prasugrel

A

P2Y1/P2Y12 receptor inhibits ADP-induced platelet aggregation
Oral
irreversable
Used for- coronary intervention

20
Q

Ticagrelor

A

P2Y1/P2Y12 receptor inhibits ADP-induced platelet aggregation
Oral
CYP2C19
Used for- angina, thrombus, coronary intervention

21
Q

Abciximab

A

GbIIb/IIIa antagonist
IV administration
antibody that prevents fibrinogen binding with vW factor etc
used with LMWH

22
Q

Eptifibatide

A 
GbIIb/IIIa antagonist
IV administration
KGD blocks binding of fibrinogen
competitive inhibitor
renal clearance
used with LMWH

Pharm Block 2 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions