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Pharm Block 2 > Histamine > Flashcards

Histamine Flashcards

1
Q

Diphenhydramine

A 
First Gen H1 receptor Blocker
Non specific effect
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
CNS-Sedation, stimulation(kids), Motion sickness (anti-cholinergic)
Local anesthetic
Most sedation of First gen
Sleeping tabs, Vestibular disturbances, early parkinsons
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2
Q

Dimenhydrinate

A 
First Gen H1 receptor Blocker
Non specific effect
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
CNS-Sedation, stimulation(kids), Motion sickness (anti-cholinergic)
Local anesthetic
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3
Q

Chlorpheniramine

A 
First Gen H1 receptor Blocker
Non specific effect
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
CNS-Sedation, stimulation(kids), Motion sickness (anti-cholinergic)
Local anesthetic
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4
Q

Promethazine

A 
First Gen H1 receptor Blocker
Non specific effect
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
CNS-Sedation, stimulation(kids), Motion sickness (anti-cholinergic)
Local anesthetic
chemotherapy-induced nausea
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5
Q

Fexofenadine

A 
Second Gen H1 receptor Blocker
No CNS
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
Metabolized by CYP2A4/CYP2D6
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6
Q

Loratadine

A 
Second Gen H1 receptor Blocker
No CNS
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
Metabolized by CYP2A4/CYP2D6
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7
Q

Desloratadine

A 
Second Gen H1 receptor Blocker
No CNS
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
Metabolized by CYP2A4/CYP2D6
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8
Q

Certirizine

A 
Second Gen H1 receptor Blocker
No CNS-most sedative effect of second gen
Oral
Inhibit Vascular permeability
Suppress Itching
NO effect on BP or bronchconstriction
Metabolized by CYP2A4/CYP2D6
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9
Q

Cimetidine

A 
H2 receptor blocker
used for peptic ulcer and GERD
inhibit gastric secretion
inhibits P450 system-warfarin
adverse effects- decreased testosterone and inhibition of CYP enzyme that hydroxylates estradiol
Gynecomastia
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10
Q

Ranitidine

A

H2 receptor blocker
used for peptic ulcer and GERD
inhibit gastric secretion

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11
Q

Famotidine

A

H2 receptor blocker
used for peptic ulcer and GERD
inhibit gastric secretion

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12
Q

Cromolyn sodium

A 
inhibits release of Histamine
inhaled anti-inflammatory
stabilizes mast cells to prevent release
used for preventative asthma treatment, allergic rhinitis and conjunctivitis
NOT a rescue medicine
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13
Q

Omalizumab

A

Monoclonal antibody (anti-antibody antibody)
Subcutaneous
Decreases the amount of IgE that binds to mast cells
Major adverse side effect- life-threatening anaphylaxis and bleeding
Used for allergic asthma

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Pharm Block 2 (12 decks)

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