NSAID Flashcards
1
Q
NSAID
A
Nonsteroidal Anti-inflammatory Drugs COX inhibitors Anti-inflammatory Anti-pyretic Analgesic
2
Q
Asprin (Acetylsalicylic Acic)
A
IRREVERSIBLE COX inhibitor absorption limited by dissolution (chewing increases absorption) Buffered or enteric-coating is an option plasma bound Crosses BBB (CNS effects) renal elimination- half life dose dependent (zero order) Unique effect on Uric Acid low does decrease excretion high dose increase excretion NOT used for gout Reye's syndrome (liver failure)
3
Q
Ibuprofen
A
COX 1 and 2
2 hour half life
less GI effect than asprin
used for arthritis and acute gout
4
Q
Nabumetone
A
Pro Drug
COX2>COX1 inhibition
5
Q
Naproxen
A
COX 1 and 2
14 hour half life
less GI effect than asprin
used for arthritis, alkylosing spondylitis and acute gout
6
Q
Indomethacin
A
COX 1 and 2
90% plasma bound
3 hour half life
treat gout, arthritis and closure of patent ductus arteriosus
7
Q
Ketorolac
A
COX1 and 2
oral or intramuscular (5 days)
more analgesic and anti-pyretic
alternate for opiod
8
Q
Piroxicam
A
COX 1 and 2
50 hour half life
good treatment for arthritis due to long half life
9
Q
Sulfasalazine
A
NOT COX related effects Blocks IL-1 and TFNalpha Blocks lipoxygenase free radical scavenger inhibit NF-kB Treat ulcerative colitis, rheumatoid arthritis and ankylosing spondylitis
10
Q
Celecoxib
A
Selective COX2
CYP2C9
manage acute pain
11
Q
Acetaminophen
A
NO affinity for COX Mechanism not well understood Effect in brain NO anti-inflammatory or blood thinning effect is an analgesic and anti-pyretic liver toxicity
