Calcium Channel Blocker

Question 1

Phenylalkylamines

Answer 1

only can bind if Ca channel is open
causes some dilation
Does not effect Preload
decreased afterload, contractility, HR, AV conduction
Large first pass effect
Side effects- hypotension, CHF, AV Block
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 2

Benzothiazepines

Answer 2

only can bind if Ca channel is open
causes some dilation
Does not effect Preload
decreased afterload, contractility, HR, AV conduction
Moderate first pass effect
Side effects- hypotension, constipation, CHF, AV Block
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 3

1,4-Dihydropyridines

Answer 3

Reflex tachycardia
Voltage dependent binding
increased vasodilation when compared to other Ca Blockers
greatest reduction in afterload
no effect on HR or AV conduction
Side effects- hypotension, constipation, CHF, AV Block
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 4

Verapamil

Answer 4

only can bind if Ca channel is open
causes some dilation
Does not effect Preload
decreased afterload, contractility, HR, AV conduction
Large first pass effect
Side effects- hypotension, CHF, AV Block
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 5

Diliazem

Answer 5

only can bind if Ca channel is open
causes some dilation
Does not effect Preload
decreased afterload, contractility, HR, AV conduction
Moderate first pass effect
Side effects- hypotension, constipation, CHF, AV Block
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 6

Nifedipine

Answer 6

Reflex tachycardia
Voltage dependent binding
increased vasodilation when compared to other Ca Blockers
greatest reduction in afterload
no effect on HR or AV conduction
Side effects- hypotension
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia

Question 7

Amlodipine

Answer 7

Long Half Life
Voltage dependent binding
increased vasodilation when compared to other Ca Blockers
greatest reduction in afterload
no effect on HR or AV conduction
Side effects- hypotension
Treats- Angina pectoris, Hypertension, Supraventricular arrythmia