Steriods Flashcards
What are 5 Actions of Glucocorticoids?
- Metabolic
- Anti inflammatory
- Immunosuppressive
- CNS effects
- Mineralcorticoids
What are the 6 uses of Glucocorticoids?
- Anti inflammatory
- Immunosuppressive
- Addison’s disease
- Induce abortion last trimester
- Chemotherapy for malignant tumours
- Ketosis in cows
What are the 3 formulations of Glucocorticoids?
Oral, Injectable, Topical
What are the Oral routes of Glucocorticoids?
Prednisone, prednisolone, Vanectyl-P, dexamethasone
What re the Injectable routes of Glucocorticoids?
hydrocortisone, prednisone, methylprednisone, triamcinolone, flumethasone, betamethasone, dexamethasone, isoflupredone
What are the Topical routes of Glucocorticoids?
Hydrocortisone, bethmethasone, mixed w/ ABx
What are the short term toxicities of glucocorticoids?
- PU/PD
- increased susceptibility to infection
What are the long term toxicities of glucocorticoids?
- Iatrogenic Cushing’s
- Iatrogenic Addison’s
- Gastric ulceration
- Osteoporosis
- Pancreatitis
- Nephrotoxicity
What are the Actions of NSAIDs?
- Inhibition of PGE2
- Analgesic & anti-pyretic on brain
- Decrease platelet aggregation
What are the uses of NSAIDs?
- Analgesia
- Anti-pyretic
- Anti inflammatory
- Endo-toxic shock
- Anti-thrombotic
What are the 3 routes for NSAIDs
Oral, injectable, otic/opthalmic
What are the oral routes of NSAIDs?
Phenylbutazone, meclofenamic acid, piroxicam, ketoprofen, meloxicam, carprofen
What are the injectable routes of NSAIDs?
Phenylbutazone, meloxicam, tolfenamic acid
What are the Toxicities for NSAIDs?
Gastric irritation, ulceration, nephrotoxicity, can’t can’t metabolize & secrete as fast, hepatotoxicity, do not use on dogs and cats w/ acetaminophen, aspirin, or ibuprofen
What are the Actions of Antihistamines?
- Response to allergen
- Block histamine receptors