Multiple Drug Therapy Flashcards
What are three useful interactions?
- Summation
- Syngerism
- Antagonism
(T or F) The higher the drug concentration at a site, the faster the absorption, because of the larger difference in concentration gradients
True
(T or F) Massage and heat will decrease absorption by decreasing blood flow to the area
False
What are the 6 factors that affect the distribution of drugs?
- Concentration gradient.
- Protein binding.
- Storage in various tissues.
- Dilution in luminal fluids.
- Specialized barriers.
- Disease processes.
Drugs tend to move from an area of high concentration to one of low concentration.
Concentration Gradient
Drug in plasma is exposed to plasma proteins (albumin, globulins, glycoproteins). These proteins normally remain in the systemic circulation, because they are too large to pass through the capillary endothelial junctions
Protein Binding
Once the drug has left the plasma compartment, it may be stored in _____
Tissue
Includes:
- rumen juice;
- gut fluids;
- body cavity fluids
- joints.
Luminal Fluids
Using two or more drugs that elicit the same type of response.
Summation
When the final response to using two or more drugs together is greater than the sum of the individual responses to the drugs.
Syngerism
Some drugs exert their effect by binding with a target cell receptor and eliciting a specific cell response.
Antagonism
Degree of binding is called ____?
Affinity
A drug with a high level of affinity for the receptor, which elicits a specific response.
Agonist
A drug that has a moderate level of affinity and may elicit a response.
Partial Agonist
Block another drug from combining with a receptor and does not elicit a specific response.
Antagonist
