AntiBacterials Flashcards
Drugs under Penicillin?
Penicillin (G&V), Cloxacillin, Methicillin, Ampicillin, Amoxicillin
What is the Spectrum for Penicillin?
Broad or Narrow
What is the Action of Penicillin?
Bacterialcidal
What are the Toxicities of Penicillin?
Allergic rxn, fatal diarrhea in rodents and rabbits, disrupt GIT
Drugs under Cephalosporin?
Cephalexin, Ceftiofur
What is the Spectrum for Cephalosporin?
Broad or Narrow (depends on generation)
What is the Cephalosporin that is safe to be used in food animals?
Ceftiofur
What is the action of Cephalosporin?
Bacterialcidal
What are the Toxicities of Cephalosporin?
GIT upset, allergic rxn, Ceftiofur WD: 2 days
Drugs under Tetracyclines?
Tetracycline, oxytetracycline, doxytetracycline, chlortetracycline
What Spectrum is Tetracyclines?
Broad
What is the Action of Tetracyclines?
Bacteriostatic
What are the Toxicities or Tetracyclines?
GIT upset, tooth discolouration, esophageal stricture in cats
Drugs under Sulfonamides?
Sulfaquinolone, Sulfamethazine, Sulfa+Trimethoprim
What Spectrum is Sulfonamides?
Effective against some G+ and G- aerobes
What is the Action of Sulfonamides?
Bacteriostatic
What are the Toxicities in Sulfonamides?
KCS in dogs, salivation & gastric ulcers in cats
Drugs under Aminoglycocides?
Neomycin, Streptomysin, Amikacin, Gentamicin, Kanamycin
What Spectrum is Aminoglycocides?
Narrow (G-)
What is the Action of Aminoglycocides?
Bacterialcidal
What are the Toxicities of Aminoglycocides?
Nephrotoxitiy, ototoxicity, Hearing loss or balance (in cats)
Drugs under Lincosamides?
Lincomysin, Clindamysin, Pirlimysin
What is the Spectrum of Lincosamides?
Narrow (G+)
What is the Action of Lincosamides?
Bacteriostatic
What are the Toxicities of Lincosamides?
GIT toxicity, fatal diarrhea in horses, rabbits, ruminants, pocket pets
Drugs under Macrolides?
Erythromycin, Tylosin, Tulathromycin, Tilomicosin
What is the Spectrum of Macrolides?
Variable spectrums (G+ or G-)
What is the Action of Macrolides?
Bacteriostatic
What are the Toxicities of Macrolides?
GIT effects, IM damage, Tilomicosin is fatal to humans, horses or dogs if injected
Drugs under Fluoroquinolone’s?
Enrofloxacin, orbifloxacin, ciprofloxacin, difloxacin, danofloxacin (cattle only)
What Spectrum is Fluoroquinolone’s?
Broad
What is the Action of Fluoroquinolone’s?
Bacterialcidal
What are the Toxicities of Fluoroquinolone’s?
High TI, GIT upset, Enrofloxacin lower dose in cats (cause eye lesions), wait until after puppies plate growth closes
Drugs under Polypeptide ABx?
polymyxin B (polysporin), Bacitracin
What Spectrum is Polypeptides?
Narrow (G+ or G-)
What Action is Polypeptides?
Bacterialcidal
What are the Toxicities of Polypeptides?
Severe neurological + renal damage if given parenterally
Drugs under Chloramphenicol + Florphenicol?
Chlorphenicol and Florphenicol
What is the Spectrum of Chloraphenicol and Florphenicol?
Wide Spectrum ( G+ and G-)
What are the Toxicities of Chloramphenicol and Florphenicol?
Chlora: irreversible aplastic anemia in humans (not allowed in food animals)
Flor: GIT upset in dogs and cats, pain in Inj. set, inappetence, diarrhea, can be used in food animals
What is the Action of Chloraphenicol and Florphenicol?
Bacteriostatic
Drugs under Nitrofurans?
Nitrofurazone, Furazolidone
What Spectrum is Nitrofurans?
Broad
What is the Action is Nitrofurans?
Bacterialcidal
What are the Toxicities of Nitrofurans?
Carcinogens in humans (not in food animals), some GIT upset
Drugs under Nitroimidazole
Metronidazole
What Spectrum is Nitroimidazole’s
Against anaerobes
What Action is Nitroimidazole’s?
Bacterialcidal
What are the Toxicities of Nitroimidazoles?
Do not use in food animals, neurologic toxicity , include ataxia, head tilt, potentially reversible