AntiFungals & AntiVirals Flashcards
What is the route of Amphotericin B?
IV
What are the Action/Uses of Amphotericin B?
Highly protein bound, limit penetration of CNS, bone, and eye
What are the Toxicities of Amphotericin B?
Nephrotoxic, do not combine with other nephrotoxic drugs, cats sensitive, GI, anemia
What is the route of Griseofulvin
Oral
What is the Action of Griseofulvin?
Fungistatic
What are the Toxicities of Griseofulvin?
GIT upset, Rare: hepatotoxic/photosensitization, cat/kitten more sensitive = anemia, neurotoxicity, anorexia, vomiting, teratogenic.
What are the Toxicities of Nystatin?
Rare side effects for topical
What are the Actions/Uses of Nystatin?
Yeast infections, (combined w/ other drugs)
Drugs under Imidazoles?
Enilconazole, Miconazole, Ketoconizole, Clotrimazole, Itraconazole, Econazole
What is the route of Enilconazole?
Topical
What are the Actions/Uses of Enilconazole?
Ringworm on dogs & horses
What is the Route of Nystatin?
Oral or Topical
What are the Toxicities of Enilconazole?
Not irritating, safe if accidentally ingested while bathing
What is the Route of Miconazole?
Topical
What are the Action/Uses of Miconazole?
Topical dermatophyte infections, some yeast
What are the toxicities of Miconazole?
None
What is the Route of Ketoconazole?
Oral or Topical
What is the Action/Uses of Ketoconazole?
Yeast, dermatophytes, some systemic infections
What are the Toxicities of Ketoconazole?
oral-anorexia & vomiting, cats = liver damage, teratogenic, reversible lightening of hair
What is the Route of Clotrimazole?
Topical or Otic
What are the Action/Uses of Clotrimazole?
Topical Infections, yeast infection in ears
What are the Toxicities of Clotrimazole?
None
What is the Route of Itraconazole?
Oral (give with fatty meal)
What is the Action/Uses of Itraconazole?
Systemic mycotic (internal fungal infection) in dogs and cats, better against Candida than Keto, aspergillus & dermatophytes
What are the Toxicities of Itraconazole?
Teratogenic, GIT upset, hepatotoxicity, cutaneous rxns
What is the Route of Econazole?
Topical
What are the Action/Uses of Econazole?
Dermatophytes, yeasts, moulds
What are the Toxicities of Econazole?
Well tolerated topically
What is the Route of Interferon?
Oral, cutaneous
