sports Flashcards

1
Q

ben Johnson (Canadian athlete)

A

most responsible for change of attitude

won premiere gold but lost it because he tested positive in enhancive substances

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2
Q

johnson’s drug invented by

A

John Manson - stanozolol patent

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3
Q

when was adrenaline used as a drug?

A

1901

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4
Q

why was adrenaline not ideal?

A

short duration of action and required iv injection

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5
Q

what is amphetamine?

A

used for cold symptoms and a good decongestant

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6
Q

what was used in wars

A

methamphetamine and pervitin

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7
Q

when did olympics restrict drug use and when was first testing done?

A

1967 in 1968 grenlobe

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8
Q

why were the banned?

A

because it was harmful to the athlete

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9
Q

who injected themselves with bull testicle

A

fritz pregl & Oskar zoth

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10
Q

how did the first isolation of the male sex hormone

A

40 kg of bull testicle to a 20 mg of male sex hornmone

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11
Q

what was the semi-synthesis in 1935

A

cholesterol to testosterone

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12
Q

what was inmate rehab

A

starving to death

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13
Q

what first used testoresone

A

horse races

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14
Q

what was the first human use of testosterone

A

soviet athletes in 1950s

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15
Q

what did testosterone do?

A

improved strength and build up muscle

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16
Q

what are the effects of extra testosterone?

A

anabolic: reduce side effects and for wasted conditions

androgenic: body facial hair, deeper voice, heavy brow, acne, etsticle shrinkage, clitoral enlargement, increase sex drive

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17
Q

what was the process of steroid testing?

A

Manfred hopper ruined it and changed the system in East Germans and banned in 1977

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18
Q

what was the doping lab in east germany

A

used Gas chromatograph and mass spectrometer

measures T to E ratio

19
Q

what is Gas chromatograph ?

A

sorts molecules based on speed and time: mixture is passed thru a tube with a sticky substance (measures amounts)

20
Q

what is mass spectrometer?

A

throws molecules in a magnetic flied and molecules fall apart and obtains a fingerprint (used to identify compounds)

21
Q

what is the masking agent for steroid testing?

A

masks the presence of extra testosterone by injecting epitestosterone

22
Q

how did they interfere with testing

A

adds detergent to alcohol to pee

urine switching

23
Q

plants and animals have diff amounts of 13 C??

A

true

24
Q

effects of steroids?

A

doesn’t build muscle (only helps build withe exercise)

liver damage, heart damage, reproductive effects

25
Q

what are anabolic steroids

A

speed recovery and speed training

26
Q

why are effects are difficult to measure

A

athletes vary doses, mix steroids, take large doses and keep their methods secret

27
Q

what are designer steroids

A

designed to avoid detection and no testing done

28
Q

what is tetrahydragestrinone

A

“the clear” and undetectable before 2002

29
Q

when are steroids safe>

A

used properly under medical supervision and limited dosing

30
Q

desire to win makes athletes??

A

push the limits

31
Q

what do red blood cells do?

A

only carry oxygen and made in bone marrow

32
Q

what is blood doping

A

removes blood from athlete and concentrates red blood cells and store them

as the athlete’s body replaces them during 3 months before the comp

athletes now have improved o2 capacity

33
Q

when was blood doping used

A

ed burke = usci in 1983

Danny van haute = olympic trials 1984

us cycling banned doping 1985

34
Q

why is EPO (protein) used instead of a transfusion?

A

helps patient make their own blood

35
Q

why are blood transfusions important in medicine?

A

risk of infection and rejection

36
Q

why are animals not an ideal protein source

A

supply is limited and not human proteins (don’t work as well in humans - possibility of rejection) and small risk of contamination

37
Q

why are cadavers not ideal source for human proteins

A

poor drug source

38
Q

what is recombinant protein

A

males human protein from bacteria and yeast

39
Q

how is human protein made

A

in bacteria/yeast, inserts human gene in a bacteria, removes it from chromosome and inserts in plasmid then genetic engineering

40
Q

what is better than animal protein and why

A

recombinant protein because is human, safe and make large quantities

41
Q

recombinant EPO is one of the best drugs in the last ???

A

30 years

42
Q

testing EPO was impossible

A

true and can detect using antibodies and is easy to hide

43
Q

what is the ON model ?

A

detects recent use (hemogoblin, EPO, soluble transferrin receptor)

44
Q

what is OFF model

A

detects longer term use (2-3 weeks)
(hemoglobin, reticulocytes, EPO)