Pain Flashcards

1
Q

per year how much prescription in USA

A

$470 billion

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2
Q

over the counter price

A

35$ per year (no prescription needed)

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3
Q

top OTC meds?

A
  • cough and cold ($8.2 billion)
  • pain reliever ($4.1 billion)
  • antacid (2.7 billion)
  • toothpaste (1.5 billion)
  • laxative (1.3 billion)
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4
Q

3 important considerations

A

safety, indication (what to use for and use), counter-indications

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5
Q

dose makes the ___ and ____?

A

drug and poison

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6
Q

what is most common OTC drug

A

pain killers ($4.1 billion)

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7
Q

what is salicylates

A

found in willow trees and Sumerians used for pain and inflammation

also in poplar, beech and wintergreen

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8
Q

what is doctrine of signatures?

A

association between disease and cure (ex ppl who lives near swamps get malaria and willows grow in swamps)

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9
Q

willow bark will cure ___ and what is active ingredient?

A

fever and salicin

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10
Q

when was salicylic acid was discovered in

A

1829

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11
Q

salicylic acid is ____ and where does it come from?

A

analgesic, antipyretic and antiflammatory and comes from coal tar

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12
Q

Felix Hoffman

A

took salicylic acid for pain and suffered from stomach problems

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13
Q

process of drug optimization is?

A

changed the chemical structure and taste less bitter with no stomach irritation (salicylic acid to acetasalicylic acid)

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14
Q

aspirin initially sold as ??

A

sold as a powder

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15
Q

what is ASA

A

acetassalicylic acid (same thing as aspirin)

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16
Q

benefits as ASA

A

pain, fever, inflammation and reduces heart attack risk

17
Q

side effects?

A

tinnitus ( more than 10 tablets ). stomach irritation, interferes with blood clotting and death

18
Q

ASA is not effective for?

A

visceral pain

19
Q

what is used to help to protect stomach?

A

prostaglandins (decreases acid production and increases mucus production)

20
Q

side effects of aspirin

A

causes acid damage in stomach

21
Q

bufferins?

A

contains an acid

22
Q

cause vs association

A

association between 2 things doesn’t mean one thing caused the other

23
Q

cause requires a ??

A

body of evidence and control experiments

24
Q

phenacetin

A

both drugs turned to acetaminophen in body (1947)

25
Q

acetaminophen (Tylenol) and stomach irritation?

A

weak irritation

26
Q

Tylenol

A

more than 60 tablets = death

27
Q

Tylenol benefits

A

pain and fever

28
Q

side effect?

A

liver toxicity

29
Q

ibuprofen 1961

A

OTC

30
Q

what does it inhibit?

A

cyclooxygenase (blocks enzyme)

31
Q

benefits?

A

pain, fever and inflammation

32
Q

side effect

A

reduced blood clotting and stomach irritation

33
Q

examples of ibuprofen

A

Advil, naproxen, Motrin

34
Q

top pain relievers in North America?

A

acetaminophen 43%
ASA 28%
ibuprofen 26%
naproxen 3%

35
Q

which drug prevent heart attacks and rye syndrome

A

ASA

36
Q

effect of COX-1 inhibition

A

stomach, and ulcers (harmful)

37
Q

effects of COX-2

A

reduces pain, inflammation and fever (beneficial)