Spirochetes

Question 1

Borrelia burgdorferi

Answer 1

the agent that causes Lyme disease! transmitted by ticks (Ixodes scapularis)

Question 2

Lyme Disease Life Cycle lasts how long?

Answer 2

2 years!!

Question 3

Erythema chronicum migrans

Answer 3

rash caused by Lyme disease

Question 4

Borrelia pathogenesis

Answer 4

induces cyst formation and can regerminate into the spiral form, evade immunity, could be connected with MS and Alzheimer’s

Question 5

Antigenic Variation of Outer Surface Proteins for Vaccines for Borrelia?

Answer 5

OspA is present in the tick, changes to OspC in humans; regulated by increased temperature and chemical factors in host blood; OspC complexes with Salp15 in salivary glands and when they bind it evades antibodies?

Question 6

How is leptospirosis transmitted?

Answer 6

urine

Question 7

Major Affected Organs of Lepto (2)?

Answer 7

liver and kidneys

Question 8

In what cells does lepto multiply?

Answer 8

endothelium in capillaries

Question 9

Which causes disease more often - host-adapted or non-host-adapted lepto?

Answer 9

host-adapted

Question 10

Which causes more severe disease - host-adapted or non-host-adapted lepto?

Answer 10

trick question, it’s not related!

Question 11

Brachyspira hyodysenteriae

Answer 11

swine dysentery/necrohemorrhagic enteritis (bloody diarrhea in post-weaning/growers (8-14 weeks))

Question 12

Can Brachyspira hyodysenteriae cause swine dysentery on its own?

Answer 12

no, generally part of a secondary infection (B. fragilis or Fusobacterium)

Question 13

Diagnostic Marker for Brachyspira piloscoli (swine colitis)?

Answer 13

end-on-end attachment to the luminal epithelium on the electron microscope!