CMN

Question 1

Why are these pathogens grouped together?

Answer 1

they all produce mycolic acid

Question 2

Cord factor (TDM)

Answer 2

virulence factor that’s a specific type of mycolic acid, induces granulomatous rxns

Question 3

Mycobactin

Answer 3

iron chelator needed for growth

Question 4

Why do you need glycerol to culture Mycobacterium?

Answer 4

glycerol is needed to synthesize mycolic acids

Question 5

Treatments for Mycobacteria?

Answer 5

1:1000 bleach and 2% NaOH (they are resistant to both acid and alkali)

Question 6

Mycobacterium tuberculosis

Answer 6

infects alveolar macrophages

Question 7

Mycobacterium bovis

Answer 7

reportable, TB in cattle, zoonotic

Question 8

Mycobacterium avium subsp. paratuberculosis (MAP)

Answer 8

reportable, causes Johne’s disease!!!

Question 9

Problems with Mycobacterium treatment?

Answer 9

difficult, long course, resistance develops rapidly

Question 10

Unique ID feature of Corynebacterium?

Answer 10

club shaped; store inorganic phosphate in older cells that look like metachromatic granules

Question 11

Is corynebacterium responsible for disease?

Answer 11

it can be, but it’s commensal so could be on anything!

Question 12

Caseous Lymphadenitis

Answer 12

Corynebacterium pseudotuberculosis makes cheesy lymph nodes in sheep and goats, abscesses possible with systemic spread

Question 13

Corynebacterium renale

Answer 13

short stumpy rods, causes pizzle rot (urine scald from ammonia and infection)