Specific Athero Flashcards
What is atherosclerosis
Focal disease of the intimacy of large/small arteries
Cholesterol levels for HIGH risk
> 6.5mmol/l
5risk factors of atherosclerosis
Older age
Male
Smoking
Hypertension
Dyslipideaemia
SM migrate from where to where
Caused by what stimulation
Tunica media to intima
PDGF / TGF-G
If atherosclerosis is in these 3 places it will lead to coronary heart diseas
Left anterior descending
Left circumflex
Right coronary artery
Why does angina pectoris occur?
Decrease in O2 saturation
Caused by ischaemia of myocardium from atherosclerosis in coronary
Necrosis can spread from where to where leading to what
Sub endocardium into epicardium
Scar tissue formation
Plaque growth and size of lumen decreasing
As plaque builds = remodelling of arterial walls
Once plaque reaches 40% does the lumen size decrease
Glagovian effect
How do Organic nitrates work
Reduce preload
Decrease workload
Increased coronary H.flow
Decreasing afterload
What do statins mimic
Mevalonate
Inhibits HMG-Reductase = decrease in cholesterol synthesis
What can aspirin do
Prevent platelet aggregation
Decrease TPR/BP = workload decreasing
Name an organic nitrate drug
What does it cause (2)
GTN
Arteriolar dilation - increased coronary HF + decreasing workload/afterload
Venous dilation -decreases preload = decreased workload
