Asthma Essay Flashcards by ryan seed | Brainscape

Q

What can LFT distinguish

A

Difference between obstructive and restrictive

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Q

FEV1 /FVC ratio for asthma

FEV1

A

0.7

<80% of what’s predicted

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Q

What are bronchospasms caused by

A

Bronchial hyper-responsiveness.

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Q

Intrinsic asthma has what 2 subsets

A

Exercise induced asthma (12%)

Aspirin induced asthma (14)

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Q

Extrinsic asthma can be categorised by what?

A

Elevated IgE

Type 1 hypersensitivity

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Q

Aspirin induced asthma is characterised by what 2 things

A

Eosinphillic infiltration

Acute attacks of dyspnea

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Q

Exercise induced asthma can lead to what 2 things

A

Hyperventilation

Irritation

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Q

Exercise induced asthma has what 2 diagnostics

A

Children-cardiac abnormalities

Adult-obesity

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Q

What 3 things increase risk of asthma

A

Family history

GERD

Smoking

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Q

What cytokine imbalance is there

A

TH2 (il-4)

Th1 (il-2)

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Q

Triggers of asthma

A

Pollen

Pets

Bacteria

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Q

Ipratropium bromide binds to what inhibiting what?

A

Binds to AcH

Stops M3 bonding

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Q

Omalizumab binds to what?

A

IgE FC regions

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Q

Cromolyn sodium can be given to who

A

Pregnant women

Slow onset

no side effect

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Q

Salmeterol acts for how long

A

15hours

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Q

How long does salbutamol last for

A

2-3 hours

Q

What is the first line defence for asthma

A

Salbutamol

Q

What can be given alone for mild-moderate asthma

A

SABA/LABA

Q

Anti-cholinergics

A

Atropine

Q

What does ipratropium bromide have

A

Affinity but not efficacy

Q

What does Montelukast bind to

A

Leukotrine receptor

Blocks LTD4 binding

Q

How is omalizumab given

A

IV

Broken down in stomach

Q

Xanthines work by inhibiting what

A

Inflammation cell activation