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Biochem > Specialized Lipids > Flashcards

Specialized Lipids Flashcards

1
Q

Precursor of Icosandoid

A

Derived from linoleic acid or directly from arachidonic acid

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2
Q

5C ring

A

Prostaglandins

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3
Q

6C ring

A

Thromboxanes

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4
Q

No ring

A

Leukotrienes

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5
Q

Synthesis of arachidonic acid from linoleic acid

A

Esterification requiring 2 different desaturases

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6
Q

Initial synthesis of arachidonic acid

A

Phospholipid–>Arachidonic acid via PLA2 (blocked by corticosteroids)

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7
Q

Mobilization of arachidonic acid to…

A

PGH2 via prostaglandin endoperoxide synthase complex

Prostaglandin and thromboxane precursor

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8
Q

In most tissues; needed for maintenance of healthy gastric tissue, renal homeostasis, and promoting platelet aggregation

A

COX-1

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9
Q

Synthesized in response to products of activated immune and inflammatory cells

A

COX-2

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10
Q

Leukotriene synthesis

A

Arachidonic acid to 5-HPETE via 5-lipooxygenase

5-HPETE to LTA-4

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Biochem (29 decks)

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